Veterinarians are uniquely qualified to conduct biomedical research in the field of comparative medicine using animal models, which have been instrumental in understanding the pathogenesis and mechanism of human diseases. Unfortunately, the majority of veterinarians do not pursue research careers, in part due to the lack of research training opportunities. Consequently, there is a critical shortage of veterinarians with research backgrounds in academic institutions, government and corporate settings across the nation.
The National Institutes of Health has funded a post-DVM "Animal Model Research for Veterinarians (AMRV)" training program at the Virginia-Maryland College of Veterinary Medicine (VA-MD Vet Med). This program will train veterinarians in the skills of a researcher, and help them launch a successful research career in the areas of animal models of infectious diseases, immunology, molecular biology, physiology, toxicology, and nutrition. Mentors participating in this training program are conducting cutting-edge research in the areas of animal models for human diseases, and their research projects are well funded by the National Institutes of Health.
Trainees will be required to enter a M.S. or Ph.D. graduate program that will expose them to state-of-the-art research skills and challenge them to become independent problem-solvers. At the end of the training program, trainees are expected to launch an independent biomedical research career, and assume leadership roles related to the nation's biomedical research agenda in academia, government, and industry.
X.J. Meng, MD, PhDProgram DirectorUniversity Distinguished ProfessorDepartment of Biomedical Sciences and Pathobiology
Ansar Ahmed, DVM, PhDProgram Co-DirectorAssociate Dean for Research and Graduate StudiesProfessor of Immunology
Susan RosebroughProgram Support Staff
Immunology and Inflammation
Ansar Ahmed, DVM, PhD, Associate Dean for Research and Graduate Studies, and Professor of Immunology ( email@example.com, 540-231-5591). By using relevant animal models for inflammation and autoimmune diseases, the laboratory focus is to investigate: (1) the molecular basis of how pro-inflammatory cytokines are induced and decipher aberrant cell signaling events; (2) why these disorders occur predominantly in females and (3) the role of microRNAs in autoimmune and inflammatory diseases.
Christopher Reilly, Associate Professor and Discipline Chair of Physiology in the Edward Via Virginia College of Osteopathic Medicine, Adjunct faculty in the College of Veterinary Medicine (firstname.lastname@example.org, 540-231-5345). Dr. Reilly's lab focuses on defining the molecular mechanisms and signal transduction cascades involved in inflammation associated with lupus nephritis. His research uses both in vivo and in vitro mouse models to dissect the role of inflammatory mediators involved in disease.
Irving Coy Allen, PhD, Assistant Professor in the Department of Biomedical Sciences and Pathobiology (email@example.com, 540-231-7551). Dr. Allen’s research is focused on deciphering the contribution of innate immune system signaling pathways in host-pathogen recognition and inflammation driven tumorigenesis. His research uses both in vitro techniques and in vivo animal models to elucidate disease pathobiology.
XJ Meng, M.D., PhD, University Distinguished Professor in the Department of Biomedical Sciences and Pathobiology ( firstname.lastname@example.org, 540-231-6912). Dr. Meng's research interests focus on emerging and re-emerging viral diseases of human and veterinary public health importance, animal models for human viral diseases, and development of vaccines against viruses of public health and economic importance. Viruses being studied in his lab include hepatitis E virus (human, swine, and avian hepatitis E viruses), and porcine circovirus, porcine reproductive and respiratory syndrome virus.
Frank Pierson, DVM, PhD, Diplomate ACPV, Professor of Biosecurity and Infection Control, Department of Population Health Sciences (email@example.com, 540-231-7823). Dr. Pierson's research interests and funding are broad with regard to infectious disease and vaccinology. Ongoing work is exploring the pathophysiology of siadenoviral infections and multi-factorial diseases of poultry, bioremediation of foodborne Salmonella sp., hepatitis E virus, and anti-tubercular vaccines.
Lijuan Yuan, PhD Assistant Professor in the Department of Biomedical Sciences and Pathobiology ( firstname.lastname@example.org, 540-231-9053). Dr. Yuan's research focuses on animal models for human enteric viral diseases. Currently, she is using gnotobiotic pig models of human rotavirus and norovirus infection and disease to study the mechanism of immune modulation by probiotics and to evaluate and improve the protective efficacy of human rotavirus and norovirus vaccines. Dr. Yuan studied the immunogenicity and protective efficacy of various vaccine formulations, adjuvants, and immunization routes in gnotobiotic pig models.
Zachary Adelman, PhD Assistant Professor in the Department of Entomology (email@example.com, 540-231-6614). Dr. Adelman's research focuses on the interactions between arthropod-borne viruses and the insect vectors responsible for their transmission to humans. His research is conducted using BSL2 and BSL3 infectious agents such as chikungunya virus, yellow fever virus, and the dengue viruses. Both invertebrate and vertebrate systems are used as animal models for human disease.
Kevin Myles, PhD Assistant Professor in the Department of Entomology (firstname.lastname@example.org, 540-231-6158). Dr. Myles's research focuses on small RNA-directed antiviral immune responses and he is currently using mosquito-borne alphaviruses and flaviviruses to study these innate immune responses. These viruses are ideal for studies comparing the antiviral immune responses of vertebrate and invertebrate animals, as their natural maintenance cycles involve alternating replication in both host types.
Marion Ehrich, PhD Professor of Toxicology/Pharmacology in the Department of Biomedical Sciences and Pathobiology ( email@example.com, 540-231-4938). Dr. Ehrich's research examines derivatized fullerenes for their capability to ameliorate acute toxicities and decrease dermal penetration of organophosphorus (OP) surrogates for chemical threat agents (nerve 'gases'). In vitro screening has resulted in identification of several compounds that have the potential to be effective, but in vitro results need validation in animal models before they can be considered for use in people.
Terry Hrubec, DVM, PhD Assistant Professor in the Department of Anatomy in the Edward Via Virginia College of Osteopathic Medicine, Adjunct faculty in the College of Veterinary Medicine (firstname.lastname@example.org, 540-231-1702). Dr. Hrubec's research focuses on determining the mechanisms regulating embryonic and fetal development to create interventions that can prevent birth defects caused by environmental teratogenic exposure. Her research uses both rats and mice to model possible human health effects from acute and chronic environmental teratogen exposure and explores ways to mitigate adverse birth outcomes.
Thomas Inzana, PhD Tyler J. and Francis F. Young Chair of Bacteriology in the Department of Biomedical Sciences and Pathobiology (email@example.com, 540-231-4692). Dr. Inzana's research encompasses molecular work on the virulence properties of bacterial pathogens, including the select agents Francisella tularensis and Brucella abortus, methicillin-resistant Staphylococcus aureus (MRSA), the bovine respiratory pathogen Histophilus somni, and the swine pathogen Haemophilus parasuis. The host immune response to these pathogens and virulence factors is investigated to develop improved vaccines and diagnostic tests. Photonic biosensors are being developed for most of these pathogens, and H. somni is being used as a model to study in vivo biofilm formation and regulatory aspects of polymicrobial infections. Vaccines for F. tularensis, H. somni, and H. parasuis are being developed based on live attenuated mutants or subunit antigens.
Nammalwar Sriranganathan, BVSc., MVSc., PhD Professor in the Department of Biomedical Sciences and Pathobiology ( firstname.lastname@example.org, 540-231-7171). Dr. Sriranganathan's primary goal is to develop alternate treatment strategies by improving the bioavailability of therapeutic agents and by targeting specific cells using block-copolymers and amorphous nanoparticles. Infectious diseases targeted in his research include brucellosis, tuberculosis, and salmonellosis. Dr. Sriraganathan's long-term research effort has also been focused on the development of vaccines against brucellosis in animals and humans and the development of multivalent vaccines.
Nutrition and Obesity
Josep Bassagaanya-Riera, DVM, PhD Associate Professor in the Virginia Bioinformatics Institute, Adjunct Professor in the Department of Biomedical Sciences and Pathobiology (email@example.com, 540-231-7421). Dr. Bassaganya-Riera leads the Nutritional Immunology and Molecular Nutrition Group (NIG) at VBI, which is a transdisciplinary research group working at the interface of nutrition, immunology, and inflammation. He has a demonstrated track record of biomedical research using in vitro systems, mouse and pig models of metabolic and inflammatory diseases, as well as human clinical studies. Modulating inflammation and immunity in white adipose tissue as a means of improving peripheral insulin sensitization is a major research thrust of his group.
Deborah Good, PhD Associate Professor in the Department of Human Nutrition, Foods, and Exercise in the College of Agriculture and Life Sciences (firstname.lastname@example.org, 540-231-0430). Dr. Good's laboratory studies hypothalamic gene expression, especially as it relates to the regulation of body weight, exercise, fat deposition in muscle, and motivated behaviors. Her laboratory uses animal models including transgenic and knockout mice, and cattle and has collaborations with individuals studying humans and pigs.
Matthew Hulver, PhD Assistant Professor in the Department of Human Nutrition, Foods, and Exercise in the College of Agriculture and Life Sciences (email@example.com, 540-231-7354). Dr. Hulver's research focuses on the role of local pro-inflammatory responses in skeletal muscle metabolic dysregulation (reduced oxidative capacity and insulin resistance). He is currently using skeletal muscle-specific TLR4 transgenic and knock-out mice as animal model systems to study the mechanisms of TLR4-mediated perturbations in skeletal muscle metabolism.
Eva Schmelz, PhD Associate Professor in the Department of Human Nutrition, Foods, and Exercise in the College of Agriculture and Life Sciences (firstname.lastname@example.org, 540-231-3649). Dr. Schmelz's work focuses on the use of dietary sphingolipids in cancer prevention. Her laboratory has published the first reports on the prevention of colon cancer by dietary complex sphingolipids. Her laboratory is especially interested in identifying the cell targets of these compounds, and the effect on low-grade inflammation that drives tumorigenesis.
Michelle Theus, PhD, Assistant professor in the Department of Biomedical Sciences and Pathobiology (email@example.com, 540-231-0909). Dr. Theus studies the mechanism(s) by which Eph receptor tyrosine kinases regulate cerebral arteriole collateral development and injury-induced remodeling. She uses a genetic approach to understand how Eph signaling impedes the formation of the arteriole collateral network and how this ultimately influences collateral blood flow during acute, sub-acute and chronic phases of repair in several models including focal cerebral ischemia and traumatic brain injury. The long-term goal of Dr. Thesus’s research is to identify effective, safe, and feasible drug targets that enhance revascularization of damaged CNS tissue and help promote integration of novel CNS compatible biomaterials.
- Annual stipend at approximately $41,000 with minimal 2 years experience
- Tuition waiver
- Meeting travel allowance
The T32 training program is available to U.S. citizens or permanent residents with an earned D.V.M. or V.M.D. degree.
- All T32 AMRV post-DVM trainees are required to enter a graduate program (M.S. or Ph.D.).
- Prospective trainees should complete an application for graduate admission to the Biomedical and Veterinary Science (BMVS) graduate program through the Virginia Tech Graduate School online application system. Please explicitly indicate that you are applying for the "NIH T32 Post-DVM Training Program" on your application.
- Please contact firstname.lastname@example.org if you have any questions regarding the application process or the T32 training program.
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