Biomedical Sciences & Pathobiology Faculty

William R. Huckle, MS, PhD

Associate Professor
Cell Biology/Pharmacology
Biomedical Sciences & Pathobiology


  • 1988
    PhD, Pharmacology
    University of Iowa
    Iowa City, IA
  • 1981
    MS, Biochemistry
    Virginia Tech
    Blacksburg, VA
  • 1978
    BA, Chemistry
    Williams College
    Williamstown, MA

Research Interests

  • Intracellular signaling mechanisms
  • Regulation of growth factor receptor mRNA variants
  • Maintenance and growth of blood vessels in cardiovascular disease and cancer
  • Development of vascular networks during pregnancy

Professional Experience

  • 1999 – Present
    Associate Professor
    Virginia-Maryland College of Veterinary Medicine
    Virginia Tech
    Blacksburg, VA
  • 1992 – 1999
    Research Fellow
    Merck & Company
    West Point, PA
  • 1988 – 1992
    Post-doctoral Fellow/Research Assistant Professor
    University of North Carolina-Chapel Hill
  • 1983 – 1984
    Staff Biochemist
    GIBCO-BRL/Life Technologies
    Gaithersburg, MD

Selected Publications

  1. Huckle, W.R., and Roche, R.I. (2004) Post-transcriptional control of expression of sFlt-1, an endogenous inhibitor of vascular endothelial growth factor, J. Cell. Biochem. 93:120-132.
  2. Troy, G.C., Huckle, W.R., Rossmeisl, J.H., Panciera, D., Lanz, O., Robertson, J.L., Ward, D.L. (2006) Endostatin and vascular endothelial growth factor concentrations in healthy dogs and dogs with selected neoplasias, J. Vet. Int. Med. 20:144-150.
  3. MacLean, H.N., J.A. Abbott, D.L. Ward, W.R. Huckle, D. Sisson and R.L. Pyle (2006) N-terminal atrial natriuretic peptide immunoreactivity in cats with hypertrophic cardiomyopathy, J. Vet. Int. Med. 20:284-289.
  4. Paye, J.M.D., Akers, R.M., Huckle, W.R., Forsten-Williams, K. (2007) Production of insulin-like growth factor-I (IGF-I) impacts paracellular transport across epithelial cells in vitro, Cell Commun. Adhes. 14:85-98.
  5. Rossmeisl, J.H., Duncan, R.B., Huckle, W.R., Troy, G.C. (2007) Vascular endothelial growth factor expression in dogs with primary intracranial neoplasms, Am. J. Vet. Res. 68:1239–1245.
  6. Peralta, O.A., W.R. Huckle, W.H. Eyestone (2011) Expression and knockdown of cellular prion protein (PrPC) in differentiating mouse embryonic stem cells, Differentiation 81:68–77.
  7. Sandberg, C.A., I.P. Herring, W.R. Huckle, T. LeRoith, J.P.Pickett, J.H. Rossmeisl (2012) Aqueous humor vascular endothelial growth factor in dogs: Association with intraocular disease and the development of pre-iridal fibrovascular membrane, Vet. Ophthalmol. 15 Suppl 1:21-30.
  8. Peralta OA, Huckle WR, Eyestone WH. (2012) Developmental expression of the cellular prion protein (PrP(C)) in bovine embryos. Mol Reprod Dev. 79:488-498.
  9. Binder DR, Herring IP, Zimmerman KL, Pickett JP, Huckle WR. (2012) Expression of vascular endothelial growth factor receptor-1 and -2 in normal and diseased canine eyes, Vet. Ophthalmol. 15:223-230.
  10. Sa, Q., Ochaia, E., Tiwari, A., Huckle, W.R., Eyestone, W.H., Saunders, T.L., and Suzuki, Y. (2015) Cutting Edge: IFN-γ produced by brain-resident cells is crucial to control cerebral infection with Toxoplasma gondii, J Immunol. 195:796-800.