We offer clinical research studies in a variety of species to find or develop new treatments, therapies, and diagnostic tools. New studies are added regularly. Each of the studies listed on this page is currently seeking participants.
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The American Veterinary Medical Association clinical research database lists hundreds of ongoing studies at sites throughout the U.S. and Canada.
Purpose: To correlate gait changes with pre and post-shoeing hoof measurements in normal and lame horses.
This study takes place at the Virginia Tech Marion duPont Scott Equine Medical Center in Leesburg, VA .
Field evaluation of a rapid, mobile, novel sequencing technology for the detection of Equine Herpesvirus-1 in equine nasal secretions
Purpose: To evaluate a novel, DNA sequencing modality for diagnosing Equine herpesvirus-1 via nasal swab samples in outbreak scenarios and to further characterize the molecular epidemiology of the virus.
Purpose: To evaluate a comprehensive margin evaluation after surgical scar revision for dogs with previously-diagnosed soft tissue sarcomas, mast cell tumors, and other dermal / subcutaneous tumors.
Use of the Spatiotemporal and Kinetic Gait Variables for Differentiation of Spinal Ataxia and Bilateral Pelvic Limb Orthopedic Disease in Dogs
Purpose: To describe gait parameters of dogs with pelvic limb ataxia or pelvic limb lameness and to determine if it is possible to discriminate cases based on spatiotemporal and kinetic variables in absence of a clinical examination.
Purpose: To determine acute and cumulative dosing safety of the chemotherapy drug oxaliplatin in dogs with cancer, and to measure the preliminary effectiveness of the drug.
Purpose: To use patient-derived models of cancer from dogs and humans to identify new therapies to treat cancers that affect both species, with a particular focus on sarcomas.
Purpose: To identify the approximate duration of time for thyroid hormone levels to return to normal following nonthyroidal illness resolution.
Minimally invasive, integrated endoscopic hemilaminectomy for Hansen Type I intervertebral disc herniation in chondrodystrophic dogs
Purpose: To evaluate a minimally invasive surgical approach to the spinal cord to address intervertebral disc herniation.
Purpose: In this study, we will compare two kinds of cardiac imaging—2D-transthoracic echocardiography and the 3D-transthoracic echocardiography to assess the ability of each to detect mitral valve prolapse.
Purpose: To determine if increased lipid levels in dogs lower gall bladder contractions and thus increase the risk of developing a serious condition called gallbladder mucoceles.
Three-dimensional echocardiographic determinants of the age of onset of myxomatous mitral valve disease in Cavalier King Charles Spaniels
Purpose: To map the hearts of the Cavaliers using specialized software and 3-D echocardiogram and predict future onset and severity of mitral valve disease.
Investigation of the immunostimulatory response to high intensity focused ultrasound in dogs with naturally-occurring solid tumors
Purpose: To determine if the application of high-intensity focused ultrasound (HIFU) can stimulate an anti-tumor immune response in canine patients with naturally-occurring solid tumors.
Effect of treatment with spironolactone in dogs with pulmonary hypertension and myxomatous mitral valve disease
Purpose: To test whether treatment with the diuretic drug spironolactone, in addition to conventional therapy for congestive heart failure (CHF), will improve pulmonary hypertension caused by mitral valve disease.
Purpose: To determine the genetic basis of the disseminated form of Histiocytic Sarcoma and ultimately identify potential therapeutic targets.
Purpose: To determine the safety and effectiveness of a new chemotherapy drug and drug delivery method in the treatment of brain tumors (gliomas) in dogs.
Purpose: To establish the safety and efficacy of a Partial (Cupless) Hip Replacement System as an alternative to traditional hip replacement in the management of lameness arising from the coxofemoral joint.
Exploratory study of an oral blood-brain barrier penetrant, procaspase-3 activator (PAC-1) in combination with hydroxyurea for treatment of canine meningioma
Purpose: To determine whether treatment with the oral chemotherapy drug procaspase-3 activator (PAC-1), in combination with the oral drug hydroxyurea, can provide safe and effective treatment of canine meningiomas.
Purpose: To further evaluate the safety and feasibility of MRI-guided High-Frequency Irreversible Electroporation (HFIRE) for the treatment of canine brain tumors.
Purpose: To understand more about how EPM affects the immune system of horses, and discover how we might improve the diagnosis and treatment of the disease.
Identification of a genetic predisposition for Equine Protozoal Myeloencephalitis (EPM) susceptibility and associated gene dysregulation in clinically affected horses
Purpose: To determine if there is an underlying genetic predisposition for horses that develop EPM, including chronically affected horses who either fail to respond to treatment or suffer recurrent disease after ceasing treatment.