Important Update About Clinical Trials
The Veterinary Teaching Hospital at the Virginia-Maryland College of Veterinary Medicine has implemented measures to minimize the risk and slow the transmission of Covid-19.
These measures may affect our ability to conduct clinical trials. The studies listed below are open. This list will be updated regularly to reflect current circumstances.
We are continuing to monitor this rapidly evolving situation. Please review the Veterinary Teaching Hospital's Covid-19 Response page for the latest information. We appreciate your patience and support, and apologize for any inconvenience. The health and safety of our clients, our patients, and our staff here at the Veterinary Teaching Hospital are central to our mission in providing the highest quality of care.
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The American Veterinary Medical Association clinical research database lists hundreds of ongoing studies at sites throughout the U.S. and Canada.
Clinical and echocardiographic predictors of outcomes in dogs with degenerative mitral valve disease
Purpose: To evaluate the clinical utility of resting respiratory rate and four different echocardiographic measurements of left atrial dimensions in predicting the onset of congestive heart failure in dogs with myxomatous mitral valve disease.
Pilot study of partial ablation using high-intensity focused ultrasound (HIFU) in feline injection site sarcomas
Purpose: To determine if high-intensity focused ultrasound (HIFU), a treatment that can destroy tissue using sound waves, will result in tumor cell death and immunologic activation in cats with injection site sarcomas.
Field evaluation of a rapid, mobile, novel sequencing technology for the detection of Equine Herpesvirus-1 in equine nasal secretions
Purpose: To evaluate a novel, DNA sequencing modality for diagnosing Equine herpesvirus-1 via nasal swab samples in outbreak scenarios and to further characterize the molecular epidemiology of the virus.
Purpose: In this study, we will compare two kinds of cardiac imaging—2D-transthoracic echocardiography and the 3D-transthoracic echocardiography to assess the ability of each to detect mitral valve prolapse.
The Effect of a Modified Approach on Early Weight Bearing Following Tibial Plateau Leveling Osteotomy in Dogs
Purpose: To determine if a modified approach to Tibial Plateau Leveling Osteotomy (TPLO), which allows improved preservation of the muscle attachments, will lead to earlier weight bearing and faster resolution of lameness following TPLO surgery.
Investigation of the immunostimulatory response of mechanical high intensity focused ultrasound (histotripsy) on naturally-occurring solid tumors
Purpose: To determine if histotripsy, a novel treatment that can destroy tissue without radiation or heat, can effectively treat canine soft tissue sarcomas.
Evaluation of high-frequency irreversible electroporation (H-FIRE) for treatment of canine lung tumors
Purpose: To evaluate the feasibility, safety, and immune effects of using a novel non-thermal ablation technique, high-frequency irreversible electroporation (H-FIRE), for treating canine lung tumors.
Evaluation of high-frequency irreversible electroporation (H-FIRE) for treatment of canine insulinoma
Purpose: To evaluate the feasibility, safety, and tumor immune effects of using a novel non-thermal ablation technique, high-frequency irreversible electroporation (H-FIRE), for treating canine insulinoma.
Purpose: To determine if histotripsy, a novel treatment that can destroy tissue without radiation or heat, can effectively treat canine osteosarcoma.
Purpose:To determine the accuracy and feasibility of flash glucose monitoring systems in diabetic cats.
Purpose: To identify the approximate duration of time for thyroid hormone levels to return to normal following nonthyroidal illness resolution.
Purpose: To understand more about how EPM affects the immune system of horses, and discover how we might improve the diagnosis and treatment of the disease.
Identification of a genetic predisposition for Equine Protozoal Myeloencephalitis (EPM) susceptibility and associated gene dysregulation in clinically affected horses
Purpose: To determine if there is an underlying genetic predisposition for horses that develop EPM, including chronically affected horses who either fail to respond to treatment or suffer recurrent disease after ceasing treatment.
Exploratory study of an oral blood-brain barrier penetrant, procaspase-3 activator (PAC-1) in combination with hydroxyurea for treatment of canine meningioma
Purpose: To determine whether treatment with the oral chemotherapy drug procaspase-3 activator (PAC-1), in combination with the oral drug hydroxyurea, can provide safe and effective treatment of canine meningiomas.
Purpose: To use patient-derived models of cancer from dogs and humans to identify new therapies to treat cancers that affect both species, with a particular focus on sarcomas.
Purpose: To evaluate a comprehensive margin evaluation after surgical scar revision for dogs with previously-diagnosed soft tissue sarcomas, mast cell tumors, and other dermal / subcutaneous tumors.
Use of the Spatiotemporal and Kinetic Gait Variables for Differentiation of Spinal Ataxia and Bilateral Pelvic Limb Orthopedic Disease in Dogs
Purpose: To describe gait parameters of dogs with pelvic limb ataxia or pelvic limb lameness and to determine if it is possible to discriminate cases based on spatiotemporal and kinetic variables in absence of a clinical examination.
Three-dimensional echocardiographic determinants of the age of onset of myxomatous mitral valve disease in Cavalier King Charles Spaniels
Purpose: To map the hearts of the Cavaliers using specialized software and 3-D echocardiogram and predict future onset and severity of mitral valve disease.
Purpose: To determine if increased lipid levels in dogs lower gall bladder contractions and thus increase the risk of developing a serious condition called gallbladder mucoceles.
Effect of treatment with spironolactone in dogs with pulmonary hypertension and myxomatous mitral valve disease
Purpose: To test whether treatment with the diuretic drug spironolactone, in addition to conventional therapy for congestive heart failure (CHF), will improve pulmonary hypertension caused by mitral valve disease.
Purpose: To further evaluate the safety and feasibility of MRI-guided High-Frequency Irreversible Electroporation (HFIRE) for the treatment of canine brain tumors.
Purpose: To determine the safety and effectiveness of a new chemotherapy drug and drug delivery method in the treatment of brain tumors (gliomas) in dogs.