We offer clinical research studies in a variety of species to find or develop new treatments, therapies, and diagnostic tools. New studies are added regularly. Each of the studies listed on this page is currently seeking participants.
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The American Veterinary Medical Association clinical research database lists hundreds of ongoing studies at sites throughout the U.S. and Canada.
Purpose: To correlate gait changes with pre and post-shoeing hoof measurements in normal and lame horses.
This study takes place at the Virginia Tech Marion duPont Scott Equine Medical Center in Leesburg, VA .
Purpose: To use patient-derived models of cancer from dogs and humans to identify new therapies to treat cancers that affect both species, with a particular focus on sarcomas.
Minimally invasive, integrated endoscopic hemilaminectomy for Hansen Type I intervertebral disc herniation in chondrodystrophic dogs
Purpose: To evaluate a minimally invasive surgical approach to the spinal cord to address intervertebral disc herniation.
Purpose: In this study, we will compare two kinds of cardiac imaging—2D-transthoracic echocardiography and the 3D-transthoracic echocardiography to assess the ability of each to detect mitral valve prolapse.
Purpose: To determine if increased lipid levels in dogs lower gall bladder contractions and thus increase the risk of developing a serious condition called gallbladder mucoceles.
Three-dimensional echocardiographic determinants of the age of onset of myxomatous mitral valve disease in Cavalier King Charles Spaniels
Purpose: To map the hearts of the Cavaliers using specialized software and 3-D echocardiogram and predict future onset and severity of mitral valve disease.
Purpose: To compare markers of blood clot formation in hyperthyroid cats and healthy cats. We’re also evaluating markers of blood clot formation in hyperthyroid cats before and after treatment with radioiodine therapy and correlate those results with ultrasound scans of the heart.
Optical coherence tomography for surgical margin assessment: The cutting-edge for feline injection-site sarcomas
Purpose: To evaluate the accuracy of an imaging method (optical coherence tomography) for detection of any cancer cells that are left behind following surgical removal of injection-site sarcomas in cats.
Investigation of the immunostimulatory response to high intensity focused ultrasound in dogs with naturally-occurring solid tumors
Purpose: To determine if the application of high-intensity focused ultrasound (HIFU) can stimulate an anti-tumor immune response in canine patients with naturally-occurring solid tumors.
Purpose: To characterize and compare the appearance of the prostate following neutering in dogs of various ages to better differentiate between diseased and normal prostates.
Intranasal midazolam versus intravenous midazolam for the management of canine status epilepticus: A multicenter randomized parallel-group clinical trial
Purpose: To compare safety and effectiveness of intranasal midazolam to intravenous midazolam for treatment of status epilepticus.
Post-Operative Transcutaneous Electrical Stimulation for Reduction of Stifle Edema in Canine Patients Undergoing Tibial Plateau Leveling Osteotomy
Purpose: To evaluate the effects of electrical stimulation on post-operative edema after routine tibial plateau leveling osteotomy (TPLO) compared to routine post-operative management without electrical stimulation.
Effect of treatment with spironolactone in dogs with pulmonary hypertension and myxomatous mitral valve disease
Purpose: To test whether treatment with the diuretic drug spironolactone, in addition to conventional therapy for congestive heart failure (CHF), will improve pulmonary hypertension caused by mitral valve disease.
Purpose: To determine the genetic basis of the disseminated form of Histiocytic Sarcoma and ultimately identify potential therapeutic targets.
Purpose: To determine the safety and effectiveness of a new chemotherapy drug and drug delivery method in the treatment of brain tumors (gliomas) in dogs.
Purpose: To establish the safety and efficacy of a Partial (Cupless) Hip Replacement System as an alternative to traditional hip replacement in the management of lameness arising from the coxofemoral joint.
Exploratory study of an oral blood-brain barrier penetrant, procaspase-3 activator (PAC-1) in combination with hydroxyurea for treatment of canine meningioma
Purpose: To determine whether treatment with the oral chemotherapy drug procaspase-3 activator (PAC-1), in combination with the oral drug hydroxyurea, can provide safe and effective treatment of canine meningiomas.
Purpose: To understand more about how EPM affects the immune system of horses, and discover how we might improve the diagnosis and treatment of the disease.
Identification of a genetic predisposition for Equine Protozoal Myeloencephalitis (EPM) susceptibility and associated gene dysregulation in clinically affected horses
Purpose: To determine if there is an underlying genetic predisposition for horses that develop EPM, including chronically affected horses who either fail to respond to treatment or suffer recurrent disease after ceasing treatment.