- Perturbation of gut microbiota has been shown to be associated with autoimmune disorders. However, little is known about the role of gut microbiota in systemic lupus erythematosus. We aim to better our understanding of the pathogenesis of the disease by studying lupus-associated gut microbiota in both mouse and human.
- Lupus nephritis, a leading cause of death in patients with lupus, manifests as inflammatory infiltrates in the glomeruli and tubulointerstitium of the kidney. A recent study has revealed that the severity of tubulointerstitial lesions, versus the glomerular counterpart, is a stronger predictor of prognosis in lupus nephritis. We have found that dendritic cells accumulate, specifically, in the tubulointerstitial region of nephritic kidneys for both human lupus patients and lupus-prone mice. However, their function in lupus nephritis is unknown. We thus aim to delineate the pathogenic role of renal infiltrating dendritic cells in lupus.
- Numerous mouse models have been employed to understand the pathogenesis of lupus and to test potential therapies. Although each model has unique advantages, effective treatments in mouse models often do not translate to human disease. We therefore aim to generate human-mouse chimeras for lupus research.
- Dr. Husen Zhang, Department of Civil and Environmental Engineering
- Dr. Ansar Ahmed, Department of Biomedical Sciences and Pathobiology
- Dr. Chris Reilly, Department of Biomedical Sciences and Pathobiology
- Dr. Tom Cecere, Department of Biomedical Sciences and Pathobiology
- Dr. Bernard Jortner, Department of Biomedical Sciences and Pathobiology