Allen Laboratory Awards & News

2015

  • John Doran winner of the Ciordia-Stewart-Porter Undergraduate Student Paper Award at the 2015 Southeastern Society of Parasitologists joint meeting with The Helminthological Society of Washington. Talk title: "The noncanonical NLR inflammasome modulates Toxoplasma gondii recognition and immune response."
  • Corren Freeman, 3rd Place Oral Presentation Winner of the 4th Annual Phi-Zeta Research Day at Tuskegee University. Talk title: “Interleukin-1β Inhibition Attenuates Colitis in Nlrp3-/- Mice.
  • Armand Meza selected to represent Virginia Tech and present research at the 2015 ACC Meeting of the Minds conference. Research presentation title: "Elucidating the contribution of negative regulatory NLRs in traumatic brain injury." View press release.

Lab In the News

  • NPR's Pulse of the Planet: Dr. Allen discussed the role of the immune system in cancer Listen to the program
  • NPR's Pulse of the Planet: Dr. Allen discussed the role of mutations in cancer Listen to the program
  • NPR's Pulse of the Planet: Dr. Allen discussed how cancer is analogous to a chessmaster Listen to the program
  • Dr. Allen presented a module entitled "Epithelial Cells and Their Role In Immunity" at the 2014 Modeling Mucosal Immunity Summer School and Symposium - View the module
  • VT News: Biomedical researcher produces books on innate immunity, allergic disease View press release
  • VT News: Dr. Irving Coy Allen joins college as assistant professor of inflammatory diseases - View press release

Grant Announcements

  • Evaluating NLR Modulation of Canonical and Non-Canonical NF-kB Signaling in IBD
    R03-DK105975-01, (PI: Allen; Co-I: Cecere), 07/01/15 – 06/30/17
    National Institutes of Health - NIDDK
    This proposal seeks to generate and utilize a panel of genetically modified mice targeting critical elements of the non-canonical NF-κB signaling pathway that are susceptible to cell specific Cre-recombinase disruption to determine additional mechanistic insight associated with NLR signaling during IBD and inflammation driven tumorigenesis in the colon.
  • Elucidating the Contribution and Therapeutic Potential of NLRX1 Signaling in Histiocytic Sarcoma
    Pilot Grant, (PI: Allen; Co-I: Dervisis; Co-I: Coutermarsh-Ott), 07/01/15 – 06/30/16
    VT-MD Regional College of Veterinary Medicine - IRC
    This proposal seeks to evaluate the contribution of NLRX1 in the development of the rare cancer histiocytic sarcoma in mouse and canine models. Specifically, this proposal will elucidate the role of NLRX1 in modulating AKT and NF-kB signaling in disease.
  • Harnessing CRISPR Technology for Gene Therapy Applications
    JFC Seed Proposal, (PI: Allen; Co-I: Davis), 07/01/15 – 06/30/16
    Virginia Tech Institute for Critical Technology and Applied Science
    This proposal aims to study the feasibility of nanoparticle delivery of the CRISPR-Cas9 system in vivo to alter genetic defects associated with hyper-inflammatory disorders in adult animals.
  • Novel vaccine system against viral infections
    Seed Grant, (Co-PI: Allen; Co-PI: Zhang), 07/01/15 – 06/30/17
    Virginia Tech and the University of Maryland CVM Joint Seed Grant
    The objective of this study is to explore the vp13 enhancer in Hepatitis E virus for vaccine development based on a partial product of the viral ORF2 and the FcRn-mediated IgG transfer pathway.
  • NLR Regulation of Gastrointestinal Inflammation and Tumorigenesis
    4-K01-DK092355, (PI: Allen), 07/01/11 – 06/30/16
    National Institutes of Health - NIDDK
    This proposal aims to study the contribution of the NLRP1 and NLRP3 inflammasomes and the anti-inflammatory NLR NLRP12 in colitis and colitis associated tumorigenesis.