Principal Investigator/Program Director (Last, First, Middle):

 

 

BIOGRAPHICAL SKETCH

Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person.  DO NOT EXCEED FOUR PAGES.

 

NAME

Reilly, Christopher M.

POSITION TITLE

Assistant Professor

eRA COMMONS USER NAME

creill

EDUCATION/TRAINING  (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

University of New Mexico, Albuquerque, NM

B.S.

1991

Biology

Medical College of Georgia, Augusta, GA

Ph.D.

1997

Physiology & Endocrinology

 

A.   Positions and Honors

Positions and Employment

1997-2000 Postdoctoral Fellow, Division of Rheumatology, Department of Medicine, Medical University of South Carolina, Charleston, SC

2000-2002 Assistant Professor, Division of Rheumatology, Department of Medicine, Medical University of South Carolina, Charleston, SC

2002-Present  Research Assistant Professor, Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, MD

2002-2006 Assistant Professor, Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Blacksburg, VA

2002-Present  Associate Professor, Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Blacksburg, VA

 

 

Other Experience and Professional Memberships

1998-2000    President of the post-doctoral scholars association at MUSC

1997-present   American Association of Immunologists

2002-present   Internal Association of Science Medical Educators

2002-Present  Discipline Leader of Physiology, Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Blacksburg, VA

2002    SCORE Study Section, Grant Review Committee, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS-NIH)

2004    NIH, MOSS Study Section, Grant Review committee

Honors

1996-1997       NIH Student training grant

2004    Hulda Irene Duggan Arthritis Investigator award

2004    VCOM outstanding researcher of the year award

 

 


B.  Selected Peer-reviewed Publications (in chronological order)

TM Mills, CM Reilly, and RW Lewis. (1996).  Androgen  and Penile Erection:  A Review. Journal of Andrology 17, 633-638.

TM Mills, VS Stopper, and CM Reilly. (1996). Sites of Androgenic Regulation of Cavernosal Blood Pressure During Penile Erection in the Rat.  International Journal of Impotence Research  8, 29-34.

CM Reilly, WE Cannady, VB Mahesh, VS Stopper, LM DeSevilla, and TM Mills. (1996) Duration of Estrogen exposure Prior to Follicle-Stimulating Hormone Stimulation is Critical to Granulosa Cell Growth and Differentiation  in Rats.  Biology of Reproduction 54, 1366-1342

CM Reilly, VS Stopper, and TM Mills. (1997). Androgens Modulate the Alpha  Adrenergic Responsiveness of Vascular Smooth Muscle in the Corpus Cavernosum.  Journal of Andrology 18, 26-31.

CM Reilly, P Zamorano, VS Stopper, and TM Mills. (1997). Androgenic Regulation of  NO Availability in the Rat Penile Erection. Journal of Andrology 18, 110-115.

CM Reilly, RW Lewis, VS Stopper, and TM Mills. (1997).  Androgenic Maintenance of the Rat Erectile Response Via a Non Nitric Oxide Mediated Pathway.  Journal of Andrology 18, 588-594.

TM Mills, RW Lewis VS Stopper, and   CM Reilly. (1988).The Loss of Alpha Adrenergic Effect During the Erectile Response in the Long Term Diabetic Rat.  Journal of Andrology 19, 473-478.

GS Gilkeson, C Cannon, JC Oates, CM Reilly, D Goldman, and M Petri. (1999). Correlation of Serum Measures of Nitric Oxide Production with Lupus Disease Activity. The Journal of Rheumatology 26, 318-24.

JC Oates, EF Christensen, CM Reilly, SS Self, and Gary S. Gilkeson. (1999). Prosepctive Measures of Serum 3-Nitrotyrosine Levels in Systemic Lupus Erythematosus:  Correlation with Disease Activity.  Proceedings of the Association of American Physicians 111, 611-621.

CM Reilly, JC Oates, JA Cook, JD Morrow, PV Halushka and GS Gilkeson. (2000). Prostaglandin J2 Modulation of Mesangial Cells Activation in MRL/lpr Mice.  Journal of Immunology 164 1498-1504.

K Guyton, R Bond, CM Reilly, G Gilkeson, P Halushka , and J Cook. (2001). Differential effects of 15 Deoxy delta 12-14 Prostaglandin J2 and a Peroxisome Proliferator Activated Receptor-Gamma Agonist on LPS Induced Macrophage Signaling and Mediator Production.  Journal of Leukocyte Biology. 69 631-638.

CM Reilly, JC Oates, J Sudian, MB Crosby, PV Halushka, and GS Gilkeson. (2001). Prostaglandin J2 Inhibition of Mesangial  Cell iNOS Expression. Clinical Immunolgy 98 337-345.

H Sekine, CM Reilly, ID Molano, G Garnier, A Circolo, P Ruiz, SA Boackle, and GS Gilkeson. (2001). Complement Component C3 is Not Required for Full Expression of Immune Complex Glomerulonephritis in MRL/lpr Mice.  Journal of Immunology 166 6444-6451.

JC Oates, CM Reilly, MB Crosby, and GS Gilkeson. (2002). PPAR-gamma agonists- They are Not Just for Diabetes Anymore.   Potential use for treating Chronic Inflammatory Diseases (Review). Arthritis and Rheumatism.

CM Reilly, LW Farrelly, D Viti, ST Redmond, F Hutchison, P Ruiz, P Manning, and GS Gilkeson. (2002). Modulation of Renal Disease in MRL/lpr Mice by Pharmacologic Inhibition of Inducible Nitric Oxide Synthase.  Kidney International 61:839-846.

CM Reilly and GS Gilkeson. (2002). Use of Genetic Knockouts to Modualte Disease Expession in a Murine Model of Lupus, MRL/lpr mice (Review).  Immunologic Research 25(2)143-153.

Guyton K, Zingarelli B, Ashton S, Teti G, Tempel G, Reilly C, Gilkeson G, Halushka P, Cook J. (2003). Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. Shock, 20(1):56-62.

M Masuya, CJ Drake, PA Fleming, CM Reilly, H Zeng and M Ogawa. (2003). Hematopoietic Origin of Glomerular Mesangial Cells. Blood 101(6) 2215-8.

N Mishra, CM Reilly, DR Brown, P Ruiz, GS Gilkeson, GM Kammer. (2003). Histone Deacetylase Inhibitors Downregulate Cytokine Production and Inhibit Renal Disease in the MRL/lpr Murine Model of Lupus. Journal of Clinical Investigation 111(4) 539-552.

Molano ID, Redmond S, Sekine H, Zhang XK, Reilly C, Hutchison F, Ruiz P, Gilkeson GS. (2003). Effect of genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production and renal disease in MRL/lpr mice. Clin Immunol 107(3):186-97.

 

 

 

 

G Douglas, C Reilly, MA Dooley, G Paige, G Cooper, and G Gilkeson. (2004). Angiotensin converting enzyme (I/D) and endothelial nitric oxide synthase polymorphisms in patients with systemic lupus erythematosus.  Journal of Rheumatology 31:1756-62. 

CM Reilly, N Mishra, JM Miller, D Joshi, P Ruiz, VM Richon, and GS Gilkeson. (2004). Modulation of Mesangial Cell Inflammatory Mediator Production and Autoimmunity in MRL/lpr Mice by Suberoylanilide Hydroxamic Acid, Journal of Immunology, 173:4171-8.

AB Kkein, SG Witonsky, SA Ahmed, SD Holladay, RG Gogal, L Link and CM Reilly (2006).  Impact of Different cell isolation Techniques on Lymphocyte viability and function.  Journal of Immunoassy and Immunochemistry 2006;27(1):61-76.

CM Reilly, S Olgun, D Goodwin, RM Gogal, A Santo, JW Romesburg, SA Ahemd, and GS Gilkeson.  (2006)  Interferon regulatory factor-1 gene deletion decreases glomerulonephritis in MRL/lpr mice.  European Journal of Immunology 2006 36(5):1296-308.

J Swenson, S Olgun, A. Radjavi, T. Kaur and CM Reilly.  The Effects of Buprenorphine to Reduce Pain and Distress in MRL/lpr Mice.  Submitted European J. of Pharmacology (2006)

 

C.  Research Support

Ongoing Research Support

Arthritis foundation                                                                                                      07/1/04-06/30/09

“IRF-1 deletion in MRL/lpr mice”

This project will investigate the role of IRF-1 in regulation inflammatory mediator production in lupus mice. 

Role: PI

 

Alliance for Lupus Research                                                                                02/01/06-01/31/07

“Histone Deacetylase Inhibitors are the therapeutic targets in SLE”

This project investigates the efficacy of the use of Tricostatin A and Suberolyanlike hydroxamic acid for the treatment of SLE.

Role: Investigator (PI: N. Mishra, Wake Forest Medical School)

 

Completed Research Support

NIH, National Institute of Arthritis and Musculoskeletal & Skin Diseases       09/23/02-05/31/05

“Inhibition of lupus nephritis in IRF-1 deficient mice”

This project will evaluate the role of IRF-1 in the initiation and propagation of the inflammatory response in the murine lupus kidney.

Role: PI

 

Alliance for Lupus Reserch (PI: N. Mishra, Wake Forest Medical School)    03/01/03-03/01/05

“Histone Deacetylase Inhibitors are the therapeutic targets in SLE”

This project investigates the efficacy of the use of Tricostatin A and Suberolyanlike hydroxamic acid for the treatment of SLE.

Role: Investigator

 

Dean’s Postdoctoral Research Fellowship Grant,                                         07/98-07/99

Medical University of South Carolina 

“The Role of prostaglandin J2 in lupus nephritis”

This preliminary project established the foundation for a project funded by the Arthritis Foundation.

Role: PI

 

Arthritis Foundation                                         07/99-07/02

“The role of prostaglandin J2 in lupus nephritis”

The goal of this project was to define the role of P J2 in mesangial cells in MRL/lpr mice.

Role: PI

 

AtheroGenics Inc.                                     04/01-11/01

“The role of adhesion molecule expression in lupus nephritis”

The goal of this project was to test AGI-1096 compound in lupus mice to determine if this drug has beneficial effects in the treatment of disease progression.

Role: PI

 

Research Enhancement Award Project, Veteran’s Administration                           01/01-03/02

“Inhibition of inflammatory mediator production in murine mesangial cells with suberoylanilide hydroxamic acid”

The goal of this project was to determine the concentration –response dependent effects of SAHA on the synthesis and/or induction of NO/NOS2, TNFa, IL-12, IL-6, COX-1 and COX-2 in mesangial cells of RML/lpr and BALB/c mice stimulated with LPS/IFNg

Role: PI

 

Pending Researh                                submitted 02/06

“The Role of Cerium Oxide nanoparticle in Systemic Lupus Erythematosus”

NIH R21. The goal of this proposal is to delineate the effects of cerium oxide nanoparticles on inflammation in lupus mice.

Role: PI

 

Previous supervision of Students

Margaret Elliott- PhD. 1998-2002 assisted with her project Medical University of South Carolina.  Dr. Elliott completed a post-doctorate at Nebraska

Kelly Guyton- PhD, 1997-2002 Medical University of South Carolina assisted with her project and co-authored several papers.  Currently a post-doctoral student at the MUSC

Michelle Crosby MD, PhD, 2000-2004 Medical University of South Carolina assisted with her research project and co-authored several publications.  Presently a Resident at UNC

Glenn Douglass MD, 1999-2001 Rheumatology Fellow, Medical University of South Carolina, taught laboratory techniques and procedures, co-authored a manuscript together. Currently in Private Practice in Nashville, TN

Jason Romesburg was a summer student in 2005, currently a 4th year medical student at the Virginia College of Osteopathic Medicine.  Mr. Romesburg’s work led to an abstract at ACR and a manuscript in press (see Appendix 1)

 

Current Graduate students

Jhenquan Jia Veterinary Medical Sciences (Virginia Tech) Co-mentor for his PhD (2003-present in progress)

Undine Christmann, Veterinary Medical Sciences (Virginia Tech) committee member for her PhD (2004-present).  This is a cross departmental collaboration with Mrs. Christmann’s project to investigate inflammation in bronchi in horses.

 

Current undergraduate students

Ali Radjavi senior at Vriginia Tech in the Department of Biology receiving 7 hours college credit working in my laboratory.