S. Ansar Ahmed, DVM., Ph.D.
INSTITUTION AND LOCATION
FIELD OF STUDY
The Bangalore University
Chem. Biol. Zool.
The University of Agricultural Sciences
Vet. Med. Surg.
The Murdoch University, Australia
Immunology and Immunopathology
A. Positions and Honors.
§ Instructor in Veterinary Immunology and Microbiology, Murdoch, Australia
§ Leukemia Foundation of America Fellow, Division of Clinical Immunology, Department of Medicine, The University of Texas Health Science Center at San Antonio
§ Research Instructor (’85-87), Research Assistant Professor (’87-’89) Division of Clinical Immunology, Department of Medicine, The University of Texas Health Center at San Antonio, Texas
Positions Held at the Virginia Tech (Virginia Polytechnic Institute & State University)
§ Assistant Professor in Immunology (Tenure track), Dept. of Pathobiology,Virginia-Maryland Regional College of Veterinary Medicine, VPI and SU, Blacksburg, Virginia.
§ Tenured, Associate Professor, VMRCVM, VPI & SU (VA Tech), Blacksburg, VA (’94)
§ Tenured, Professor of Immunology, VMRCVM, VPI & SU (VA Tech), Blacksburg, VA (‘01)
§ Director, Center for Molecular Medicine & Infectious Diseases, VMRCVM
Awarded all four academic merit Gold Medals (1977):
Ø UAS gold Medal for General Academic Merit
Ø Lions Club International Gold Medal
Ø Dr. S. Mohyuiddin’s Gold Medal for Veterinary
Ø Dr. Rajkumar’s Gold Medal for Veterinary
Recipient of UAS MERIT Scholarship (‘72-77)
Dr. Jawaharlal Nehru, National Award (1977)
State Government Award for Academic Merit (’78)
Ø Upgraded from MS to Ph.D.
Ø Murdoch University Scholarship Award (Australia)
Ø External Examiners’ Evaluation Category:
“Approved with Highest Enthusiasm”(’84)
Ø Murdoch University Travel Award (to present
Papers at IVth International Immunology meetings Paris (1980) and London (1980)
Post-doctoral: Leukemia Research Fellowship from the Leukemia Society of America, Inc. (1983-85)
Selected Other Honors: Membership in Federal Govt. Study Sections and Grant review Panels:
(1) ALTX-1 NIH, study section Ad Hoc Member, 2001;
(2) ALTX-4 NIH study Section, Ad Hoc Member, 2003;
(3) IRPG (Special Emphasis Panel)/ NIH - 2003;
(4) Special Emphasis Panel/ ZRG1 GMA-3 /NIH-2003;
(5) XNDA-NIH study section, Ad Hoc Member 2004;
(6) ZRG Innate Immunity and Inflammation/NIH, Nov. 04-05, 2004;
(7) NSF- Integrative Animal Biology Program, Nov. 01, 2004;
External Reviewer for Several Research Foundations::
(1) The Blowitz-Ridgeway Foundation;
(2) JW McLaughlin Foundation;
(3) John Sealy Endowment Foundation);
(4) ASPIRES Grant Review Panel, VT, 2004.
Research Awards and Other Academic Recognition:
(1) Smith Kline Beecham award for Excellence in Research on Animal Health, 1994;
(2) Pfizer award for Research Excellence- 2003;
(3) Member, Phi Zeta National Honor Society and
(4) Early Promotion and Tenure, 1994;
(5) VMRCVM Excellence in Teaching Award, 1992;
(6) Early Promotion & Tenure, 1994;
(7) External reviewer for promotion and Tenure dossiers from several Universities.
Selected Recent Invited Presentations: (Last 5 years only)::
(1) Keynote Speaker “Animal Models of Estrogen Effects on Immunity” presented at: ISNIM/ AAI, Experimental Biology’2001, Orlando, FL, 3/31/ 01; (2) Invited Speaker “Sex hormones, Immunity & Autoimmunity” presented at: “ B cells and autoimmunity”, Satellite Meeting to the 11th inter. Cong. of Immunol,7/19-21/01 Bergen, Norway; (3) Panelist & Invited Speaker:, “Focus on Sex Differences In Immunology & Autoimmunity”, Boston, 11/8/01; (4) Invited Speaker: ”Autoimmunity and Cell Signaling: Role of estrogenic compounds., Vaccine Technology and Immune Responses, Riva, San Vitale, Switzerland, April 3-5, 2002; (5) Invited Speaker :“Molecular Regulation of interferong by estrogens: Implications to Immunity and Autoimmune Diseases”, University of Maryland Seminar Series, College Park, MD., May 1, 2002; (6) Invited Speaker: “Estrogenic Endocrine Disruptors and Immune Effects”, NIEHS meeting, Institute of Advanced Learning and Research, Danville,VA., May 10, 2002; (7) Invited Speaker: NIEHS Center “ Molecular Signaling In Immune Cells by Estogenic Compounds”, Galveston, May 6, 2002, TX (8) “ Estrogenic compounds Regulate Interferong: Implications to Autoimmunity”, Immunology Council Speaker at the John Hopkins Center for Autoimmune Disease Research and PAHO/WHO Collaborating Center for Autoimmune Disorders, November 5, 2002, Baltimore, Maryland; (9) Chairman of the Break out Group, “Translation Research: Systemic Autoimmune Diseases” at the Autoimmune Diseases and Environmental Factors, Raliegh-Durham, NIEHS (Sponsored by NIAID and NIEHS). My role was to lead a group of nationally recognized scientists to identify areas of research priorities, present these for discussion to all attendees of the meeting and generate a document of recommendation of research priorities to the NIH; (10) “The Immune System – A Target for Environmental Estrogens" Presented at the Third International Conference on Sex Hormones, Pregnancy, and the Rheumatic Diseases. Oct. 21-24, 2002, New Orleans; (11) Co-Chairman of Sex Hormones and the Connective Tissue Diseases I: The role of Gender and Hormones in connective tissue Disease” Third International Conference on Sex Hormones, Pregnancy, and the Rheumatic Diseases. Oct. 23, 2002, New Orleans; (12) “The immune system- the other target tissue of estrogens: Implications to immunity and autoimmunity” University of Virginia, June 19-20, 2003; (13) Chairman, “Translation Research: Systemic Autoimmune Diseases” Break out Research Focus Group at the Autoimmune Diseases and Environmental Factors, Raliegh-Durham, NIEHS, (Sponsored by NIAID and NIEHS). Feb. 4, 2003; (14) National Institute of Aging – “Endocrine-Immune System Interactions in Aging”, April 12-13, Potomac, MD.
Selected Peer-reviewed Publications (over 65):
Verthelyi D and Ansar Ahmed S: Estrogen increases the number of plasma cells and enhances their autoantibody production in non-autoimmune C57BL/6J mice. Cellular Immunology, 189: 125-134, 1998
Boehm GW, Sherman GF, Hoplight BJ, Hyde LA, Bradway DM, Galaburda AM, Ansar Ahmed S, Denenberg VH. Learning in year-old female autoimmune BXSB mice. Physiology and Behavior 64: 75-82, 1998
Ansar Ahmed S and Talal, N: “Sex hormones, Immunity and Autoimmune Diseases- an update”
In : A decade in Autoimmunity. (ed. Y. Shoenfeld), Chapter 38; 325-329, 1998
Ansar Ahmed S, Hissong BD, Verthelyi D, Donner K, Becker K, Karpuzoglu-Sahin, E: “Gender and Risk of Autoimmune Diseases”. Environmental Health Perspectives. 107: 681-686,1999 (Invited Paper)
Walker C, Ansar Ahmed S, Brown T, Shuk-Mei Ho, Lucier G, Russo J, Weigel N, Weise T, Vandenbergh J. Species, Interindividual and Tissue Specificity in Endocrine Signaling Environmental Health Perspectives, 107: 619-624, 1999 (Invited Paper)
Donner kJ, Becker KM, Hissong BD, Ansar Ahmed S: Comparison of multiple assays for kinetic detection of apoptosis in thymocytes exposed to dexamethasone or diethylstilbestrol. Cytometry 35: 80-90, 1999
Gogal RM, Ansar Ahmed S, Smith S, Holladay SD: Mandates to develop non-mammalian models for chemical immunotoxicity evaluations: Is fish a viable alternative to fish? Toxicology Letters 106: 89-92,1999
Gogal RM Jr., Ansar Ahmed S, Walsh JE, Holladay SD., Galaburda AM, Rosen GD: Induced minor malformations in the neocortex of normal mice do not alter immunological functions. Immunological Investigations, 29 (3) 299-318, 2000
Ansar Ahmed S: The immune system as a potential target for environmental estrogens (endocrine disruptors): An area of growing importance. Toxicology ,150: 191-206, 2000
Ansar Ahmed S: Should humoral immunity exclusively mean antibodies? A new expanded definition to reflect a subspecialty of immunology. Immunology Letters 75:89-90, 2001
Karpuzoglu-Sahin E, Zhi-jun, Yin, Sriranganathan N, Ansar Ahmed S: Effects of long-term estrogen treatment on interferon-g, interleukin 2, and interleukin 4 gene expression and protein synthesis in spleen and thymus of normal C57BL/6 mice Cytokine 14 (4) 208-217, 2001.
Karpuzoglu-Sahin E, Hissong, BD, Ansar Ahmed S: Interferon-g levels are up-regulated by 17-b-estradiol and diethylstilbestrol Journal of Reproductive Immunology , 52: 113-127, 2001
Rosypal AC, Lindsay, DL, Duncan, Jr. R, Ansar Ahmed S, Zajac, AM and Dubey JP: " Mice lacking the gene for inducible or endothelial nitric oxide are resistant to sporocyst-induced Sarcocystis neurona Infections . Veterinary Parasitology 103: 315-321, 2002
Calemine, JB., Gogal, RM., Jr., Lengi, A., Sponenberg, P., Ansar Ahmed S Immunomodualtion by diethylstilbestrol is does and gender related: Effects on thymocyte apoptosis and mitogen-induced proliferation. Toxicology: 178: 101-118, 2002
Calemine, JB., Zelenka, J.,Lengi, A., Ansar Ahmed S: The immune system of geriatric mice is modulated by estrogenic compounds (Diethylstilbestrol, Genestien, a-Zearalanol): Effects on mRNA and protein.
Toxicology, 194: 115-128, 2003
Witonsky, S., Gogal, RM., Jr., Buechner-Maxwell, V., Ansar Ahmed S. The immunological analysis on horse peripheral blood samples stored for twenty-four hours. American Journal of Veterinary Research, American Journal of Vet Research. Aug; 64(8): 1003-9, 2003
Blaylock BL, Ansar Ahmed S, and Holladay SD Prenatal Immunotoxicant Exposure and Autoimmune Disease. In: Developmental Immunotoxicology. Editor, S.D. Holladay. CRC Press LLC, Boca Raton, FL., 2004. (In press)
Karpuzoglu-Sahin E, Gogal, RM. Jr., Hardy, C., Ansar Ahmed S. Short-term administration of 17-bestradiol in outbred mice induced changes in lymphoid organ, but not reproductive organ. Immunological Investigations (In Press) 2004
Ansar Ahmed S Karpuzoglu-Sahin E. “Estrogen, Interferon-gamma, and Lupus” In: Molecular Autoimmunity. Edited by: M. Zouali, Kluwer Academic Publshers, New York, (In press) 2004 (Invited Paper)
Original papers that are cited in over 100 peer-reviewed publications
(Source: Institute for Scientific Information, Web of Science, Citation Databases):
Cited in 426 publications -Ansar Ahmed S, Penhale WJ, Talal N: “Sex hormones, Immune responses and Autoimmune responses: Mechanisms of Sex Hormone Action”. American Journal of Pathology 121:5 31-559, 1985.
Cited in 311 publications -Ansar Ahmed S, Gogal, R.M. Jr., Walsh, J.E. A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: An alternative to 3H-thymidine incorporation assay.
Journal of Immunological Methods 170: 211-224, 1994.
Cited in 122 publications- Ansar Ahmed S, Dauphinee MJ, Talal, N.: Effect of short term administration of sex hormones on normal and autoimmune mice.Journal of Immunology 134: 204-210,1985 (
Cited in 112 Publications-Lucas JA, Ansar Ahmed S, Casey ML, MacDonald PC: Prevention of autoantibody formation and prolonged survival in New-Zealand black New-Zealand white F1-mice fed dehydroisoandrosterone Journal Of Clinical Investigation 75 (6): 2091-2093 1985.
STUDIES SUPPORTED IN PART BY GRANTS FROM THE FOLLOWING AGENCIES:
ASPIRES, Virginia Tech University Competitive Program
USDA/AH&D Federal Govt. formula Funds;
USDA/AH&D Federal Govt. formula Funds
Lupus Foundation of America
Leukemia Foundation of America