Biomedical Sciences & Pathobiology Faculty

Lijuan Yuan, PhD

Associate Professor
Virology and Immunology
Department of Biomedical Sciences & Pathobiology

Education

  • 1996 – 2000
    PhD, Immunology and Virology
    Food Animal Health Research Program
    Department of Veterinary Preventive Medicine
    The Ohio State University
  • 1988 – 1991
    MS, Immunology and Virology
    Laboratory of Biochemistry and Immunology
    Capital Institute of Pediatrics
    Beijing, China
  • 1983 – 1985
    Diploma, Biochemistry
    Beijing University
    Beijing, China
  • 1978 – 1981
    Diploma, Pharmaceutics
    Beijing Health School
    Beijing, China

Research Interests

  • Gnotobiotic pig (wild type, gene knockout and transgenic) model of human enteric virus infection and diseases
  • Study mechanisms of probiotics’ immune modulating effects on innate and adaptive immunity induced by virus infection and vaccines in the gnotobiotic pig model of human rotavirus infection and disease
  • Study norovirus pathogenesis and immunity in gnotobiotic pigs and to evaluate norovirus vaccines and potential anti-norovirus drugs

Professional Experience

  • 2013 – Present
    Associate Professor
    Virology and Immunology
    Center for Molecular Medicine and Infectious Diseases
    Department of Biomedical Sciences and Pathobiology
    Virginia-Maryland College of Veterinary Medicine
    Virginia Tech
    Blacksburg, VA
  • 2007 – 2013
    Assistant Professor
    Virology and Immunology
    Center for Molecular Medicine and Infectious Diseases
    Department of Biomedical Sciences and Pathobiology
    Virginia-Maryland College of Veterinary Medicine
    Virginia Tech
    Blacksburg, VA
  • 2002 – 2007
    Adjunct Assistant Professor and Research Scientist
    Food Animal Health Research Program
    Department of Veterinary Preventive Medicine, OARDC
    The Ohio State University
    Wooster, OH
  • 2000 – 2002
    Postdoctoral Fellow
    Laboratory of Infectious Diseases
    National Institute of Allergy and Infectious Diseases
    National Institutes of Health
    Bethesda, MD
  • 1996 – 2000
    Graduate Research Associate
    Food Animal Health Research Program
    Department of Veterinary Preventive Medicine, OARDC
    The Ohio State University
    Wooster, OH
  • 1993 – 1996
    Visiting Scientist
    Food Animal Health Research Program
    Department of Veterinary Preventive Medicine, OARDC
    The Ohio State University
    Wooster, OH
  • 1991 – 1993
    Assistant Research Fellow
    Beijing Municipal Laboratory of Infection and Immunity
    Capital Institute of Pediatrics
    Beijing, China
  • 1988 – 1991
    Graduate Research Associate
    Laboratory of Biochemistry and Immunology
    Capital Institute of Pediatrics
    Beijing, China
  • 1986 – 1988
    Research Assistant
    Laboratory of Biochemistry and Immunology
    Capital Institute of Pediatrics
    Beijing, China
  • 1985 – 1986
    Research Assistant
    Research and Development Center for Infants and Children’s Food and Nutrition
    Capital Institute of Pediatrics
    Beijing, China
  • 1981 – 1983
    Job Title
    Beijing Thoracic Hospital
    Beijing, China

Honors & Awards

  • 2011
    Pfizer Award for Research Excellence
  • 2009
    American Society for Microbiology International Professorship Award for Asia
  • 2009
    Honorary Professor
    Yunnan Agricultural University
    China
  • 2001
    Recipient, William E. Krauss Director’s Award for Excellence in Research
    Ohio Agricultural Research and Development Center
    The Ohio State University
  • 2000
    Recipient, Phi Zeta, National Honor Society of Veterinary Medicine membership
    The Ohio State University
  • 1999
    Recipient, CRWAD Outstanding Graduate Student Poster Presentation Award
    American Association of Veterinary Immunologists
    Chicago, IL
  • 1999 – 2000
    Recipient, Presidential Fellowship
    The Ohio State University
  • 1999 – 2000
    Recipient, Charles E. Thorne Memorial Assistantship
    OARDC
  • 1998
    Recipient, Phi Kappa Phi Honor Society membership
    The Ohio State University
  • 1998
    Recipient, Phi Zeta Student Research Award for poster presentation
    College of Veterinary Medicine
    The Ohio State University, at Advances in Veterinary Medicine Day
  • 1994
    Recipient, First Class Award for "Molecular epidemiology study of VP4 and VP7 genotypes of rotaviruses circulating in China" from Beijing Scientific and Technologic Invention
    Municipal Committee of Science and Technology
    Beijing, China

Professional Memberships

  • American Society for Virology, Full member
  • American Society for Microbiology
  • Society for Mucosal Immunology
  • American Association for the Advancement of Science
  • American Association of Veterinary Immunologists
  • Phi Kappa Phi National Honor Society
  • Phi Zeta, The National Honor Society of Veterinary Medicine

Selected Publications

  1. Liu F, Li G, Wen K, Wu S, Zhang Y, Bui T, Yang X, Kocher J, Sun J, Jortner B, Yuan L. 2013. Lactobacillus rhamnosus GG on rotavirus induced injury of ileal epithelium in gnotobiotic pigs. Journal of Pediatric Gastroenterology & Nutrition (doi: 10.1097/MPG.0b013e3182a356e1). in press.
  2. Liu F, Wen K, Li G, Yang X, Kocher J, Bui T, Jones D, Vonck M, Pelzer K, Yuan L. 2013. Dual functions of Lactobacillus acidophilus NCFMTMin protection against rotavirus diarrhea ingnotobiotic pigs vaccinated with a human rotavirus vaccine. Journal of Pediatric Gastroenterology & Nutrition (in press).
  3. Wentzel JF, Yuan L, Rao S, van Dijk A, O’Neill HG. 2013. Consensus sequence determination and elucidation of the evolutionary history of a rotavirus Wa variant reveal a close relationship to various Wa variants derived from the original Wa strain. Infection, Genetics and Evolution (doi: 10.1016/j.meegid.2013.09.007). in press.
  4. Wu S, Yuan L, Zhang Y, Liu F, Li G, Wen K, Kocher J, Yang X, Sun J. 2013. Probiotic LGG mono-association suppresses virus-induced autophagy in gnotobiotic pig intestine. Gut Pathog. 5:22-28.
  5. Bui T, Kocher J, Li Y, Wen K, Li G, Liu F, Yang X, LeRoith T, Tan M, Xia M, Zhong W, Jiang X, Yuan L. 2013. Median infectious dose of human norovirus GII.4 in gnotobiotic pigs is decreased by simvastatin treatment and increased by age. J. Gen Virol. 94:2005-2016.
  6. Wen K, Li G, Yang X, Bui T, Bai M, Liu F, Kocher J, Yuan L. 2012. CD4+CD25-FoxP3+ regulatory cells are the predominant responding regulatory T cells after human rotavirus infection or vaccination in gnotobiotic pigs. Immunology. 137:160-171.
  7. Wen K, Bui T, Li G, Liu F, Li Y, Kocher J, Yuan L. 2012. Characterization of immune modulating functions of γδ T cell subsets in a gnotobiotic pig model of human rotavirus infection. Comp Immunol Microbiol Infect Dis. 35:289-301.
  8. Wen K, Li G, Bui T, Liu F, Li Y, Kocher J, Lin L, Yang X, Yuan L. 2012. High dose and low dose Lactobacilli acidophilus exerted opposite immune modulating effects on T cell immune responses induced by an oral human rotavirus vaccine in gnotobiotic pigs. Vaccine 30:1198-1207.
  9. Wen K, Li G, Zhang W, Azevedo MSP, Saif LJ, Liu F, Bui T, Yousef A, Yuan L. 2011. Development of γδ T cell subset responses in gnotobiotic pigs infected with human rotaviruses and colonized with probiotic lactobacilli. Vet Immunol Immunopathol14:267–275.
  10. Liu F, Li G, Wen K, Bui T, Cao D, Zhang Y, Yuan L. 2010. Porcine small intestinal epithelial cell line (IPEC-J2) of rotavirus infection as a new model for study of innate immune responses to rotaviruses and probiotics. Viral Immunology. 2010. 23:135-149.