Michelle H. Theus, PhD
Translational Biology, Medicine, and Health Graduate Program
NIH R01 Novel Cellular and Molecular Regulation of Collateral Remodeling in Ischemic StrokeCoronary and cerebrovascular disease remains the leading cause of morbidity and mortality in the US, afflicting more than 1.8 million Americans each year. Ischemic injury following vascular occlusion is often dictated by the extent and remodeling of pre-existing pial collateral or "by-pass" vessels (arterogenesis). Our overall goal is to greatly improve our mechanistic understanding of collateral remodeling and how this impacts the microenvironment in which neurons repair themselves. Novel insights into this important adaptive response to vascular obstruction will help advance collaterotherapeutics as a treatment options for neurorestoration after ischemic stroke.Grant duration: 9/2019 - 6/2024
NIH R01 Mechanisms Regulating Cerebral Arteriogenesis and NeurorestorationPromoting vascular remodeling has emerged as a potential therapeutic approach for neurorestorative therapy. Cerebral vascular trauma leads to inadequate cerebral blood flow which potentiates neuronal cell loss resulting in motor and cognitive deficits in models of brain injury. Endothelial cells lining the blood vessels actively respond to tissue trauma. Our novel findings demonstrate, cell-to-cell contact proteins called Eph receptor tyrosine kinases, and their ephrin ligand(s), are present on cerebral arteriole endothelial cells and play a central role in limiting arteriogenesis in the murine brain following injury.Grant duration: 4/2016 - 3/2021
Virginia Tech leads $2.6 million study of brain trauma, epilepsy connectionVirginia Tech is launching a $2.6 million study to determine if traumatic brain injuries can cause changes within the brain that lead to epilepsy. Funded by the nonprofit Citizens United for Research in Epilepsy (CURE) and the U.S. Department of Defense, the three-year study seeks to identify the root causes behind why a person may develop epilepsy after he or she has suffered brain trauma, including sports-related concussion and focal contusion injuries. Five Virginia Tech groups are heading the study: The School of Neuroscience, part of the College of Science; the Virginia Tech Carilion Research Institute (VTCRI); the Virginia-Maryland College of Veterinary Medicine; and the College of Engineering. All of the research leaders have wide experience in brain injury and neurological disorders; Michelle Theus will study the role of glial-stem cell interactions in post-traumatic epilepsy across various types of head traumas.
2006PhD, NeuroPathology and Laboratory MedicineMedical University of South Carolina (MUSC)Charleston, SC
1999MT (ASCP) Board CertificationClinical Laboratory Scientist Training ProgramUniversity of Texas M.D. Anderson Cancer Research CenterHouston, TX
1998BS, Clinical Laboratory Sciences, Cum Laude,Chemistry and Microbiology minorsUniversity of OhioAthens, OH
2000Histocompatibility Technical Specialist (ASHI)
1999Medical Technologist (MT) (ASCP)
1999Clinical Laboratory Scientist (National Crediting Agency)
Recent scientific discoveries have placed stem cell therapy in the spotlight for tissue repair and have raised enthusiasm amongst regenerative medicine scientists. The concept of "self-healing" using the patient's own nature stem cells is an exciting part of translational research since these cells represent a local source for cellular replacement.
The goal of my research is to understand how these innate stem cells contribute to adult central nervous system (CNS) repair following traumatic injury, an area that has very limited regenerative potential. Using a gene-targeted approach, we have identified a novel family of inhibitory proteins called Eph receptors that restrict the growth potential of adult-derived stem cells. Moreover, we hypothesize that the presence of these inhibitory molecules on circulating stem cells may limit the remodeling of the vascular network after CNS damage. Because the extent of acute cell loss and long-term functional recovery is often dictated by local blood supply, vascular repair represents an important primary target for stem cell therapy. To that end, we are currently investigating the effects of blocking Eph receptors, using innovative gene-targeted and systems approaches in combination with vessel painting, on promoting revascularization after CNS injury. These investigations overall are aimed at identifying effective, safe and feasible drug targets that promote stem cell therapy for clinical applications in CNS disorders such as ischemic stroke and traumatic brain injuries.
View publications on Michelle Theus' PubMed profile.
2018 – PresentAssociate Professor, NeuroscienceBiomedical Sciences & PathobiologyVirginia-Maryland College of Veterinary MedicineVirginia TechBlacksburg, VA
2012 – 2018Assistant Professor, NeuroscienceBiomedical Sciences & PathobiologyVirginia-Maryland College of Veterinary MedicineVirginia TechBlacksburg, VA
2006 – 2012Postdoctoral ScholarDepartment of NeurosurgeryThe Miami Project to Cure Spinal Cord ParalysisUniversity of MiamiMiami, FL
1999 – 2001Histocompatibility Technical Specialist, ASHI certifiedCleveland Clinic Organ Transplant CenterCleveland, OH
1998 – 1999Medical Technologist, Phlebotomist, ASCP certifiedM.D. Anderson Cancer Research CenterHouston, TX
- American Association for the Advancement of Science
- Society for Neuroscience
- American Society of Histocompatibility and Immunogenetics
- American Society of Clinical Laboratory Science
- American Society of Clinical Pathologists