Biomedical Sciences & Pathobiology Faculty

Xin M. Luo, PhD

Assistant Professor
Department of Biomedical Sciences & Pathobiology


  • 2006
    PhD, Immunology
    Pennsylvania State University - University Park
    University Park, PA
  • 2001
    MS, Nutritional Sciences
    Pennsylvania State University - University Park
    University Park, PA
  • 1998
    Biochemistry & Molecular Biology
    Peking University

Research Interests

The research interests in the Luo Laboratory are immunological and microbial regulation of autoimmunity and immunodeficiency. On the immunological side, we are interested in the roles of dendritic cells in inflammation; while on the microbial side, we focus on how commensal bacteria in the gut affect the host immune system, and vice versa. We utilize murine models and human patient samples to study various diseases including systemic lupus erythematosus and primary immunodeficiencies.

Professional Experience

  • 2012 – Present
    Assistant Professor
    Biomedical Sciences & Pathobiology
    Virginia-Maryland College of Veterinary Medicine
    Virginia Tech
    Blacksburg, VA
  • Sept. – Dec. 2011
    Scientist II
    Cell Signaling Technology
  • 2010 – 2011
    Research Scientist
    Division of Biology
    California Institute of Technology
  • 2005 – 2010
    Postdoctoral Fellow
    Division of Biology
    California Institute of Technology
    Mentor: David Baltimore (Nobel Laureate)

Professional Memberships

  • American Association of Immunologists (AAI)

Selected Publications

  1. Mu Q, Zhang H, Luo XM (2015) SLE: Another Autoimmune Disorder Influenced by Microbes and Diet? Frontiers in Immunology doi: 10.3389/fimmu.2015.00608.
  2. Liao X, Li S, Settlage RE, Sun S, Ren J, Reihl AM, Zhang H, Karyala SV, Reilly CM, Ahmed SA, Luo XM. (2015) Cutting Edge: Plasmacytoid Dendritic Cells in Late-Stage Lupus Mice Defective in Producing IFN-α. Journal of Immunology. 195:4578-4582.
  3. Zhang H, Luo XM (2015) Control of commensal microbiota by the adaptive immune system. Gut Microbes 6(2):156-60.
  4. Liao X, Ren J, Wei CH, Ross AC, Cecere TE, Jortner BS, Ahmed SA, Luo XM. (2015) Paradoxical effects of all-trans-retinoic acid on lupus-like disease in the MRL/lpr mouse model. PLoS One. 10(3):e0118176.
  5. Zhang H, Sparks JB, Karyala SV, Settlage R, Luo XM. (2014) Host adaptive immunity alters gut microbiota. ISME Journal 9(3):770-81.
  6. Zhang H, Liao X, Sparks JB, Luo XM. (2014) Dynamics of gut microbiota in autoimmune lupus. Applied Environmental Microbiology 80(24):7551-60.
  7. Luo XM, Lei MYY. (2012) Recombination activating gene-2 regulates CpG-mediated interferon-alpha production in mouse bone marrow-derived plasmacytoid dendritic cells. PLoS One 7(10): e47952.
  8. Luo XM, Lei MYY, Feidi RA, West AP, Balazs AB, Bjorkman PJ, Yang L, Baltimore D. (2010) Dimeric 2G12 as a potent protection against HIV-1. PLoS Pathogens 6(12): e1001225.
  9. Luo XM, Maarschalk E, O'Connell RM, Wang P, Yang L, Baltimore D. (2009) Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes. Blood 113(7): 1422-1431.
  10. Luo XM, Ross AC. (2005) Physiological and receptor-selective retinoids modulate interferon-gamma signaling by increasing the expression, nuclear localization, and functional activity of interferon regulatory factor-1. Journal of Biological Chemistry 280(43): 36228-36236.