Biomedical Sciences & Pathobiology Faculty

Neeta Jain-Gupta, PhD

Senior Research Associate
Department of Biomedical Sciences & Pathobiology

Education

  • 2009 – 2012
    PhD, Biomedical & Veterinary Sciences (Infectious Disease Microbiology & Immunology)
    Department of Biomedical Sciences & Pathobiology
    Virginia-Maryland Regional College of Veterinary Medicine
    Virginia Tech
    Blacksburg, VA, USA
  • 2006 – 2009
    MS, Biomedical & Veterinary Sciences (Infectious Disease Microbiology)
    Department of Biomedical Sciences & Pathobiology
    Virginia-Maryland Regional College of Veterinary Medicine
    Virginia Tech
    Blacksburg, VA, USA
  • 2000 – 2005
    BS, Veterinary Sciences & Animal Husbandry (B.V.Sc)
    MHOW Veterinary College
    Jawaharlal Nehru Krishi Vishwavidyalaya
    MHOW, M.P., India

Research Interests

My research interests lie in understanding host-pathogen interactions and molecular mechanism of diseases with an aim to develop therapeutics and vaccines. I am also interested in developing tools to deliver therapeutics and vaccines to enhance their efficacies in the host. In addition, we are currently developing immuno-contraceptives to control wild animal population as well as to reduce boar taint in commercial swine.

Professional Experience

  • 2015 – present
    Senior Research Associate
    Center for Molecular Medicine & Infectious Diseases
    Biomedical Sciences & Pathobiology
    Virginia-Maryland College of Veterinary Medicine
    Virginia Tech
    Blacksburg, VA
  • 2012 – 2013
    Post Doctoral Scholar
    Department of Biochemistry & Molecular Biology
    University of Chicago
    Chicago, IL
  • 2006 – 2011
    Graduate Research Assistant
    Center for Molecular Medicine & Infectious Diseases
    Department of Biomedical Sciences & Pathobiology
    Virginia-Maryland College of Veterinary Medicine
    Virginia Tech
    Blacksburg, VA

Honors & Awards

  • 2012
    Outstanding Doctoral Student
    Virginia-Maryland Regional College of Veterinary Medicine
    Virginia Tech
    Blacksburg, VA, USA
  • 2011
    Best oral presentation award at 64th Brucellosis Research Conference
    Buenos Aires, Argentina
  • 2011
    FEMS Congress Grant for Young Scientist Award at 4th Congress of European Microbiologist
    Geneva, Switzerland
  • 2010
    First prize, oral presentation
    American Association of Veterinary Immunology (AAVI) 91st CRWAD meeting
    Chicago, USA
  • 2010
    Outstanding Ph.D. presentation award
    22nd Annual Research Symposium
    Virginia-Maryland Regional College of Veterinary Medicine
    Virginia Tech
    Blacksburg, VA, USA
  • 2010
    First prize, poster competition
    Graduate Student Association Annual Research Symposium
    Blacksburg, VA, USA
  • 2008
    First prize, poster competition
    5th annual Via Research Recognition Day
    Virginia College of Osteopathic Medicine
    Blacksburg, Virginia, USA
  • 2008
    Travel Grant
    7th conference and workshop on biological barriers and Nanomedicine-Advanced drug delivery and predictive non-vivo testing technologies
    University of Saarland
    Saarbrucken, Germany

Selected Publications

  1. Dabral N., Jain-Gupta N., Seleem M. N., Sriranganathan N., Vemulapalli R. Overexpression of Brucella putative glycosyltransferase WbkA in B. abortus RB51 leads to production of exopolysaccharide. Front. Cell. Infect. Microbiol, 2015. 5 (54).
  2. Kim H.S., Willett J.W., Jain-Gupta N., Fiebig A., Crosson S. The Brucella abortus virulence regulator, LovhK, is a sensor kinase in the general stress response signaling pathway. Mol Microbiol, 2014. 94 (4): 913-25
  3. Czyz D.M., Potluri L.P., Jain-Gupta N., Riley S.P., Martinez J.J., Steck T.L., Crosson S., Shuman H.A., Gabay J.E. Host-Directed Antimicrobial Drugs with Broad-Spectrum Efficacy against Intracellular Bacterial Pathogens. MBio, 2014. 5 (4).
  4. Jain-Gupta N., Contreras-Rodriguez A., Smith G.P., Garg V.K., Witonsky S.G., Isloor S., Vemulapalli R., Boyle S.M., Sriranganathan N. Immunotherapeutics to prevent the replication of Brucella in a treatment failure mouse model. Vaccine 2014. 32(8): 918-23
  5. Jain-Gupta N., Pothayee N., Pothayee N., Tyler R., Caudell D., Balasubramaniam S., Hu N., Davis R.M., Riffle J.S., Sriranganathan N. Efficacies of gentamicin-loaded magnetite block ionomer complexes against chronic Brucella melitensis infection.Journal of Nanoparticle Research, 2013. 15 (11): 1-13
  6. Rajasekaran P., Alexander J.C., Seleem M.N., Jain N., Sriranganathan N., Wattam A. R., Setubal J.C., Boyle S.M. Peptide nucleic acids inhibit growth of Brucella suis in pure culture and in infected murine macrophages. Int J Antimicrob Agents, 2013. 41: 358-362
  7. Pothayee N., Balasubramaniam S., Pothayee N., Jain N., Hu N., Lin Y., Davis R.M., Sriranganathan N., Koretsky A.P. and Riffle J.S. Magnetic nanoclusters with hydrophilic spacing for dual drug delivery and sensitive magnetic resonance imaging. J. Mater. Chem. B, 2013. 1 (8): 1142-1149
  8. Jain-Gupta N., Contreras-Rodriguez A., Witonsky S. G., Vemulapalli R., Boyle S. M., Sriranganathan N. Pluronic P85 enhances the efficacy of outer membrane vesicles as vaccine against Brucella melitensis challenge in BALB/c mice. FEMS Immunology and Medical Microbiology, 2012. 66(3): 436-44
  9. Jain, N., S. M. Boyle, and N. Sriranganathan. Effect of exogenous erythritol on growth and survival of Brucella. Vet Microbiol, 2012.160(3-4): 513-6
  10. Pothayee, N., Pothayee N., Jain N., Hu N., Balasubramaniam S., Johnson L. M., Davis R. M., Sriranganathan N., and Riffle J. S. Magnetic block ionomer complexes for potential dual imaging and therapeutic agents. Chemistry of Materials, 2012. 24: 2056-2063.

Book Chapter

  • Avila-Calderón, E., López-Merino, A., Jain-Gupta, N., Boyle, S.M., Sriranganathan, N. & Contreras-Rodríguez, A. Outer membrane vesicles as an acellular vaccine against brucellosis. Vaccines – Benefits and Risks. 2013, ISBN: 978-1477554-95-1.