Biomedical Sciences & Pathobiology Faculty

William R. Huckle, MS, PhD

Associate Professor
Cell Biology/Pharmacology
Biomedical Sciences & Pathobiology

Education

  • 1988
    PhD, Pharmacology
    University of Iowa
    Iowa City, IA
  • 1981
    MS, Biochemistry
    Virginia Tech
    Blacksburg, VA
  • 1978
    BA, Chemistry
    Williams College
    Williamstown, MA

Research Interests

  • Intracellular signaling mechanisms
  • Regulation of growth factor receptor expression
  • Maintenance and growth of blood vessels in cardiovascular disease and cancer
  • Transgenic models of human diseases

Professional Experience

  • 1999 – Present
    Associate Professor
    Virginia-Maryland College of Veterinary Medicine
    Virginia Tech
    Blacksburg, VA
  • 1992 – 1999
    Research Fellow
    Merck & Company
    West Point, PA
  • 1988 – 1992
    Post-doctoral Fellow/Research Assistant Professor
    University of North Carolina-Chapel Hill
  • 1983 – 1984
    Staff Biochemist
    GIBCO-BRL/Life Technologies
    Gaithersburg, MD

Selected Publications

  1. MacLean, H.N., J.A. Abbott, D.L. Ward, W.R. Huckle, D. Sisson and R.L. Pyle (2005) N-terminal atrial natriuretic peptide immunoreactivity in cats with hypertrophic cardiomyopathy, J. Vet. Int. Med. (in press).
  2. Troy, G.C., Huckle, W.R., Rossmeisl, J.H., Panciera, D., Lanz, O., Robertson, J.L., Ward, D.L. (2005) Endostatin and vascular endothelial growth factor concentrations in healthy dogs and dogs with selected neoplasias, J. Vet. Int. Med. (in press).
  3. Hafez, S.A., W.R. Huckle and T. Caceci (2005) Anatomical, histological and genetic investigations of a sexually anomalous goat, Vet. Rec. (in press).
  4. Kreke, M.R., W.R. Huckle and A.S. Goldstein (2005) Intermittent fluid flow up-regulates osteoblastic maturation of bone marrow stromal cells in a temporally dependent manner Bone 36:1047-1055.
  5. Bilodeau, M.T., Balitza, A.E., Koester, T.J., Manley, P.J., Rodman, L.D., Buser-Doepner, C., Coll, K.E., Fernandes, C., Gibbs, J.B., Heimbrook, D.C., Huckle, W.R., Kohl, N., Lynch, J.J., Mao, X., McFall, R.C., McLoughlin, D., Miller-Stein, C.M., Rickert, K.W., Sepp-Lorenzino, L., Shipman, J.M., Subramanian, R., Thomas, K.A., Wong, B.K., Yu, S., Hartman, G.D. (2004) Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel. J Med Chem. 47:6363-6372.
  6. Spillman, W.B. J.L. Robertson, W.R. Huckle, B.S. Govindan and K.E. Meissner (2004) Complexity, fractals, disease time, and cancer, Phys Rev E Stat Nonlin Soft Matter Phys. 70:061911.1-12.
  7. Porter, R.M., Huckle, W.R., and Goldstein, A.S. (2003) Withdrawal of dexamethasone halts osteoblastic differentiation of bone marrow stromal cells, J. Cell. Biochem. 90:13-22.
  8. Huckle, W.R, and Roche, R.I. (2004) Post-transcriptional control of expression of sFlt-1, an endogenous inhibitor of vascular endothelial growth factor, J. Cell. Biochem. 93:120-132.
  9. Fraley, M.E., Rubino, R.S., Hoffman, W.F., Hambaugh, S.R., Arrington, K.L., Hungate, R.W., Bilodeau, M.T., Tebben, A.J., Rutledge, R.Z., Kendall, R.L., McFall, R.C., Huckle, W.R., Coll, K.E., and Thomas, K.A. (2002) Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics. Bioorg Med Chem Lett. 12:3537-3541.
  10. Huckle, W.R., Drag, M.D., Acker, W.R., Powers, M., McFall, R.C., Holder, D.J., Walsh, T.F., Schwartz, R.S., Greenlee, W.J., and Johnson, R.G. (2001) Effects of L-749,329, an ETA/ETB endothelin receptor antagonist, in a porcine coronary artery injury model of vascular restenosis. Circulation 103:1899-1905.
  11. Goldman, C.K., Kendall, R.L., Cabrera, G., Soroceanu, L., Heike, Y., Gillespie, G.Y., Siegal, G.P., Bett, A.J., Mao, X., Huckle, W.R., Thomas, K.A., and Curiel, D.T. (1998) Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis and mortality rate. Proc. Natl. Acad. Sci. USA 95:8795-8800.