Population Health Sciences Faculty

Andrea S. Bertke, PhD

Assistant Professor
Infectious Diseases
Department of Population Health Sciences

Education

  • 2007
    PhD, Emerging Infectious Diseases
    Uniformed Services University of the Health Sciences
  • 2001
    BS, Microbiology
    Bowling Green State University

Research Interests

  • Molecular mechanisms regulating herpes simplex virus latency and reactivation
  • Neuronal pathways by which HSV1 and HSV2 reach the CNS
  • Role of autonomic nervous system in HSV1 and HSV2 pathogenesis
  • Development of novel antivirals to prevent viral reactivation
  • Interactions between nociceptors and autonomic neurons

Professional Experience

  • 2012 – Present
    Assistant Professor of Infectious Diseases
    Population Health Sciences
    Virginia-Maryland College of Veterinary Medicine
    Virginia Tech
    Blacksburg, VA
  • 2014 – Present
    Assistant Professor
    Faculty of Health Sciences
    Virginia Tech
    Blacksburg, VA
  • 2009 – 2012
    Postdoctoral Fellow, Proctor Foundation
    Department of Ophthalmology
    University of California San Francisco
    San Francisco, CA
  • 2011
    Adjunct Faculty, Neural Systems Physiology
    Health Professions Certificate Program
    San Francisco State University
    San Francisco, CA
  • 2008
    Research Associate, Developmental Neuroscience
    Department of Biology
    State University of New York at Buffalo
    Buffalo, NY
  • 2007 – 2008
    Postdoctoral Fellow, Neurotropic RNA Viruses
    Department of Pathology
    University of Texas Medical Branch
    Galveston, TX
  • 2003 – 2007
    Graduate Research Assistant
    Laboratory of DNA Viruses
    Center for Biologics Evaluation and Research
    Food and Drug Administration
    Bethesda, MD

Professional Memberships

  • Society for Neuroscience
  • American Society of Microbiology

Selected Publications

  1. Lee S, Ives AM, Bertke AS. (2015). HSV-1 reactivates from autonomic ciliary ganglia independently from sensory trigeminal ganglia to cause recurrent ocular disease. J Virol, Jun 3. pii: JVI.00468-15 [Epub ahead of print] PubMed PMID: 26041294.
  2. Bertke AS, Ma A, Margolis MS, Margolis TP. (2013). Different mechanisms regulate productive herpes simplex virus 1 (HSV-1) and HSV-2 infections in adult trigeminal neurons. J Virol, 87(11):6512-6516. PubMed PMID: 23514893.
  3. Bertke AS, Apakupakul K, Ma A, Imai Y, Gussow AM, Wang K, Cohen JI, Bloom DC, Margolis TP. (2012). LAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans. PLoS One. 7(12):e53281. doi: 10.1371/journal.pone.0053281. PubMed PMID: 23300908
  4. Tang S, Bertke AS, Patel A, Margolis TP, Krause PR. (2011). Herpes simplex virus 2 microRNA miR-H6 is a novel latency-associated transcript-associated microRNA, but reduction of its expression does not influence the establishment of viral latency or the recurrence phenotype. J Virol. 85(9):4501-9. Epub 2011/02/18. doi: 10.1128/JVI.01997-10. PubMed PMID: 21325410
  5. Ohashi M, Bertke AS, Patel A, Krause PR. (2011). Spread of herpes simplex virus to the spinal cord is independent of spread to dorsal root ganglia. J Virol. 85(6):3030-2. Epub 2010/12/17. doi: 10.1128/JVI.02426-10. PubMed PMID: 21159869
  6. Bertke AS, Swanson SM, Chen J, Imai Y, Kinchington PR, Margolis TP. (2011). A5-positive primary sensory neurons are nonpermissive for productive infection with herpes simplex virus 1 in vitro. J Virol. 85(13):6669-77. doi: 10.1128/JVI.00204-11. PubMed PMID: 21507969
  7. Bertke AS, Patel A, Imai Y, Apakupakul K, Margolis TP, Krause PR. (2009). LAT exon 1 controls HSV viral species-specific phenotypes: reactivation in the guinea pig genital model and neuron subtype-specific latent expression of LAT. J Virol. Oct:83(19):10007-15. PubMed PMID: 19641003
  8. Yun NE, Peng BH, Bertke AS, Borisevich V, Smith JK, Smith JN, Poussard AL, Salazar M, Judy BM, Zacks MA, Estes DM, Paessler S. (2009). CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus. Vaccine.27(30):4064-73. PubMed PMID: 19446933.
  9. Tang S, Bertke AS, Patel A, Wang K, Cohen JI, Krause PR. (2008). An acutely and latently expressed herpes simplex virus 2 viral microRNA inhibits expression of ICP34.5, a viral neurovirulence factor. Proc Natl Acad Sci U S A. 105(31):10931-6. PubMed PMID: 18678906.
  10. Bertke AS, Patel A, Krause PR. (2007).Herpes simplex virus latency-associated transcript sequence downstream of the promoter influences type-specific reactivation and viral neurotropism. J Virol. 81(12):6605-13. PubMed PMID: 17409161.