Biomedical Sciences & Pathobiology Faculty

Irving C. Allen, MS, MBA, PhD

Assistant Professor
Inflammatory Disease
Department of Biomedical Sciences & Pathobiology


  • 2012
    Master of Business Administration, Bioscience Management
    North Carolina State University
  • 2006
    Doctor of Philosophy, Genetics and Molecular Biology
    The University of North Carolina at Chapel Hill
  • 2000
    Master of Science, Biology
    The University of North Carolina at Greensboro
  • 1997
    Bachelor of Science, Biology
    East Carolina University

Research Interests

  • Cancer immunology
  • Animal models of innate immunity
  • Animal models of allergic disease
  • Host pathogen interactions

Professional Experience

  • 2012 – Present
    Assistant Professor
    Inflammatory Disease
    Virginia-Maryland College of Veterinary Medicine
    Virginia Tech
    Blacksburg, VA
  • 2007 – 2011
    Postdoctoral Fellow/Research Associate
    Lineberger Comprehensive Cancer Center
    The University of North Carolina at Chapel Hill
    Chapel Hill, NC
  • 2001 – 2002
    Research Associate
    Center for Human Genetics
    Duke University
    Durham, NC
  • 1997 – 2001
    Laboratory Technologist I
    Laboratory Corporation of America
    Paternity Testing Division
    Burlington, NC

Professional Memberships

  • American Association of Immunologists
  • Inflammation Research Association
  • American Association for the Advancement of Science
  • American Society for Microbiology
  • Society for Mucosal Immunology

Selected Publications

  1. Schneider,M., Zimmermann,A.G., Roberts,R., Zhang,L., Swanson,K.V., Wen,H., Davis,B.K., Allen,I.C., Holl,E.K., Ye,Z., Rahman,A.H., Conti,B.J., Eitas,T., Koller,B.H., and Ting,J.P.Y. (2012). NLRC3 Attenuates TLR Signaling via Modification of TRAF6 and NF-κB. Nature Immunology. September 13(9):823-31.
  2. Allen,I.C., Wilson,J.E., Schneider, M., Lich,J.D., Authur,J.C., Woodford,R.M., Uronis,J.M., Davis,B.K., Roberts,R.A., Rogers,A.B., Herfarth,H.H., Jobin,C., and Ting, J.P.Y. (2012). NLRP12 Functions as a Negative Regulator of Noncanonical NF-κB Signaling and Tumorigenesis during Colitis Associated Cancer. Immunity. May 25;36(5):742-54.
  3. Allen,I.C., Jania,C.M., Wilson, J.E., Tekeppe,E.M., Hua,X., Brickey,W.J., Kwan,M., Koller,B.H., Tilley,S.L., Ting,J.P.Y. (2012). Analysis of NLRP3 in the Development of Allergic Airway Disease in Mice. The Journal of Immunology. Mar 15;188(6):2884-93.
  4. Allen,I.C., Lich,J.D., Arthur,J.C., Jania, C.M., Roberts, R.A., Callaway, J.B., Tilley, S.L., Ting,J.P.Y. (2012). Characterization of NLRP12 during the Development of Allergic Airway Disease in Mice. PLoS One. Jan; 7(1): e30612.
  5. Cyphert,J.*, Allen,I.C.*, Cote,R.J., Latour,A.M., Snouwaert,J.N., Coffman,T.M., and Koller,B.H. (2011). Allergic Inflammation Induces a Persistent Mechanistic Switch in Thromboxane-Mediated Airway Constriction in the Mouse. The American Journal of Physiology - Lung Cellular and Molecular Physiology. Jan;302(1):L140-51. *Authors Contributed Equally.
  6. Allen,I.C., Moore, C.B., Schneider, M., Lei, Y., Davis, B.K., Scull, M.A., Gris, D., Roney, K.E., Zimmermann, A.G., Bowzard, J.B., Ranjan, P., Monroe, K.M., Vance, R.E., Pickles, R.J., Sambhara, S., Ting, J.P.Y. (2011). NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways. Immunity. Jun 24; 34(6): 854-865.
  7. Van Deventer, H. W., Burgents, J.E., Wu, Q.P., Brickey, W.J., McFadden, R.M., Allen, I.C., Serody, J.S., Ting, J.P.Y. (2010). The inflammasome component, NLRP3, impairs antitumor vaccine by enhancing accumulation of peritumoral myeloid derived suppressor cells. Cancer Research. Dec 15;70(24):10161-9.
  8. Allen, I.C., Tekippe, E.M., Woodford, R.M., Uronis, J.M., Holl, E.K., Rogers, A.B., Herfarth, H.H., Jobin, C., Ting, J.P.Y. (2010). The NLRP3 Inflammasome Functions as a Negative Regulator of Tumorigenesis during Colitis Associated Cancer. The Journal of Experimental Medicine. May 10;207(5):1045-56.
  9. Willingham, S.B.*, Allen, I.C.*, Bergstralh, D.T.*, Brickey, W.T., Taxman, D.J., Duncan, J.A. Ting, J.P.Y. (2009). Klebsiella pneumoniae induces IL-1β release and pyronecrosis through NLRP3. The Journal of Immunology. August;183(3): 2008-15.*Authors Contributed Equally.
  10. Allen, I.C., Scull, M.A., Moore, C.B., Holl, E.K., Taxman, D.J., Guthrie, E.H., Pickles, R.J., Ting, J.P.Y. (2009). The NLRP3 Inflammasome Is Essential for the Regulation of Innate Immune Responses to Influenza A Virus Infection. Immunity. Apr;30(4):556-65.