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DBSP Faculty

Lijuan Yuan

Lijuan Yuan, Ph.D.

Assistant Professor
Virology and Immunology
Department of Biomedical Sciences & Pathobiology
 
e-mail: lyuan@vt.edu
Dr. Yuan's CV

 

Education

1996-2000 Ph.D., Immunology and Virology
Food Animal Health Research Program
Department of Veterinary Preventive Medicine
The Ohio State University
1988-1991 M.S., Immunology and Virology
Laboratory of Biochemistry and Immunology
Capital Institute of Pediatrics
Beijing, China
1983-1985 Diploma, Biochemistry
Beijing University
Beijing, China
1978-1981 Diploma, Pharmaceutics
Beijing Health School
Beijing, China

Research Interests

  • Probiotics’ effects on innate and adaptive immunity induced by virus infection and vaccines in the gnotobiotic pig model of human rotavirus infection and disease.
  • Generation of plasmid-based reverse genetic systems of rotavirus to study the determinants of pathogenicity and attenuation markers of rotaviruses and to develop new generations of rotavirus vaccines.
  • Develop a gnotobiotic pig model for noroviruses and apply this model to evaluate a panel of lead compounds which could result in the development of the first generation of antiviral drugs against noroviruses to be used in biodefense and in the prevention and control of norovirus outbreaks.

Professional Experience

July 2007-present Assistant Professor, Virology and Immunology
Center for Molecular Medicine and Infectious Diseases
Department of Biomedical Sciences and Pathobiology
VA-MD Regional College of Veterinary Medicine
Virginia Tech
2002-2007 Adjunct Assistant Professor and Research Scientist
Food Animal Health Research Program
Department of Veterinary Preventive Medicine, OARDC
The Ohio State University
Wooster, OH
2000-2002 Postdoctoral Fellow
Laboratory of Infectious Diseases
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Bethesda, Maryland
1996-2000 Graduate Research Associate
Food Animal Health Research Program
Department of Veterinary Preventive Medicine, OARDC
The Ohio State University
Wooster, OH
1993-1996 Visiting Scientist
Food Animal Health Research Program
Department of Veterinary Preventive Medicine, OARDC
The Ohio State University
Wooster, OH
1991-1993 Assistant Research Fellow
Beijing Municipal Laboratory of Infection and Immunity
Capital Institute of Pediatrics
Beijing, China
1988-1991 Graduate Research Associate
Laboratory of Biochemistry and Immunology
Capital Institute of Pediatrics
Beijing, China
1986-1988 Research Assistant
Laboratory of Biochemistry and Immunology
Capital Institute of Pediatrics
Beijing, China
1985-1986 Research Assistant
Research and Development Center for Infants and Children’s Food and Nutrition
Capital Institute of Pediatrics
Beijing, China
1981-1983 Assistant Pharmacist
Beijing Thoracic Hospital
Beijing, China

Honors & Awards

2001 Recipient, William E. Krauss Director’s Award for Excellence in Research
Ohio Agricultural Research and Development Center
The Ohio State University
2000 Recipient, Phi Zeta, National Honor Society of Veterinary Medicine membership
The Ohio State University
1999 Recipient, CRWAD Outstanding Graduate Student Poster Presentation Award
American Association of Veterinary Immunologists
Chicago, Illinois
1999-2000 Recipient, Presidential Fellowship
The Ohio State University
1999-2000 Recipient, Charles E. Thorne Memorial Assistantship
OARDC
1998 Recipient, Phi Kappa Phi Honor Society membership
The Ohio State University
1998 Recipient, Phi Zeta Student Research Award for poster presentation
College of Veterinary Medicine
The Ohio State University, at Advances in Veterinary Medicine Day
1994 Recipient, First Class Award for "Molecular epidemiology study of VP4 and VP7 genotypes of rotaviruses circulating in China" from Beijing Scientific and Technologic Invention
Municipal Committee of Science and Technology
Beijing, China

Professional Memberships

  • American Society for Virology, Full member
  • American Society for Microbiology
  • Society for Mucosal Immunology
  • American Association for the Advancement of Science
  • American Association of Veterinary Immunologists
  • Phi Kappa Phi National Honor Society
  • Phi Zeta, The National Honor Society of Veterinary Medicine

Selected Publications

  • Yuan L*, Wen K, Azevedo, MSP, Gonzalez, AM. Zhang, W, Saif LJ. 2008. Virus-specific intestinal IFN-γ producing T cell responses induced by human rotavirus infection and vaccines are correlated with protection against rotavirus diarrhea in gnotobiotic pigs. Vaccine. In press.
  • Zhang W, Azevedo MSP, Wen K, Gonzalez AM, Saif LJ, Li G, Yousef AE, Yuan L*. 2008. Probiotic Lactobacillus acidophilus enhances the immunogenicity of an oral rotavirus vaccine in gnotobiotic pigs. Vaccine. In press.
  • Zhang W, Azevedo MSP, Gonzalez A, Saif LJ, Nguyen TV, Wen K, Yousef AE, Yuan L*. 2008. Influence of probiotic lactobacilli colonization on neonatal B cell responses in a gnotobiotic pig model of human rotavirus infection and disease. Vet Immunol Immunopath. 121:222-231.
  • Zhang W, Wen K, Azevedo, MSP, Gonzalez A, Saif LJ, Yousef AE, Li G, Yuan L*. 2008. Lactic acid bacterial colonization and human rotavirus infection influence distribution and frequencies of monocytes/macrophages and dendritic cells in neonatal gnotobiotic pigs. Vet Immunol Immunopath. 122:175-181.
  • Yuan L, Stevenson G, Saif LJ. 2006. Rotavirus and Reovirus. In Diseases of Swine. 9th Edition. Edited by B. E. Straw, J. J. Zimmerman, S. D’Allaire and D. J. Taylor. Blackwell Publishing. Ames, Iowa. p435-454.
  • Yuan L*, Azevedo MSP, Gonzalez AM, Jeong K, Nguyen TV, Iosef C, Lewis P, Herrmann JE, Saif LJ. 2005. Mucosal and systemic antibody responses and protection induced by a prime/boost rotavirus-DNA vaccine in a gnotobiotic pig model. Vaccine 23:3925-3936.
  • Please see Dr. Yuan's CV (PDF) for more publications.