DBSP
Roster  DBSP Departments VA-MD Vet Med

DBSP Faculty

Lijuan Yuan

Lijuan Yuan, Ph.D.

Associate Professor
Virology and Immunology
Department of Biomedical Sciences & Pathobiology
 
e-mail: lyuan@vt.edu
Dr. Yuan's Biosketch (PDF)

Dr. Yuan's Laboratory website

 

Education

1996-2000 Ph.D., Immunology and Virology
Food Animal Health Research Program
Department of Veterinary Preventive Medicine
The Ohio State University
1988-1991 M.S., Immunology and Virology
Laboratory of Biochemistry and Immunology
Capital Institute of Pediatrics
Beijing, China
1983-1985 Diploma, Biochemistry
Beijing University
Beijing, China
1978-1981 Diploma, Pharmaceutics
Beijing Health School
Beijing, China

Research Interests

  • Gnotobiotic pig (wild type, gene knockout and transgenic) model of human enteric virus infection and diseases
  • Study mechanisms of probiotics’ immune modulating effects on innate and adaptive immunity induced by virus infection and vaccines in the gnotobiotic pig model of human rotavirus infection and disease
  • Study norovirus pathogenesis and immunity in gnotobiotic pigs and to evaluate norovirus vaccines and potential anti-norovirus drugs

Professional Experience

2013-present Associate Professor, Virology and Immunology
Center for Molecular Medicine and Infectious Diseases
Department of Biomedical Sciences and Pathobiology
VA-MD Regional College of Veterinary Medicine
Virginia Tech
2007-2013 Assistant Professor, Virology and Immunology
Center for Molecular Medicine and Infectious Diseases
Department of Biomedical Sciences and Pathobiology
VA-MD Regional College of Veterinary Medicine
Virginia Tech
2002-2007 Adjunct Assistant Professor and Research Scientist
Food Animal Health Research Program
Department of Veterinary Preventive Medicine, OARDC
The Ohio State University
Wooster, OH
2000-2002 Postdoctoral Fellow
Laboratory of Infectious Diseases
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Bethesda, Maryland
1996-2000 Graduate Research Associate
Food Animal Health Research Program
Department of Veterinary Preventive Medicine, OARDC
The Ohio State University
Wooster, OH
1993-1996 Visiting Scientist
Food Animal Health Research Program
Department of Veterinary Preventive Medicine, OARDC
The Ohio State University
Wooster, OH
1991-1993 Assistant Research Fellow
Beijing Municipal Laboratory of Infection and Immunity
Capital Institute of Pediatrics
Beijing, China
1988-1991 Graduate Research Associate
Laboratory of Biochemistry and Immunology
Capital Institute of Pediatrics
Beijing, China
1986-1988 Research Assistant
Laboratory of Biochemistry and Immunology
Capital Institute of Pediatrics
Beijing, China
1985-1986 Research Assistant
Research and Development Center for Infants and Children’s Food and Nutrition
Capital Institute of Pediatrics
Beijing, China
1981-1983 Assistant Pharmacist
Beijing Thoracic Hospital
Beijing, China

Honors & Awards

2011 Pfizer Award for Research Excellence
2009 American Society for Microbiology International Professorship Award for Asia
2009 Honorary Professor, Yunnan Agricultural University, China
2001 Recipient, William E. Krauss Director’s Award for Excellence in Research
Ohio Agricultural Research and Development Center
The Ohio State University
2000 Recipient, Phi Zeta, National Honor Society of Veterinary Medicine membership
The Ohio State University
1999 Recipient, CRWAD Outstanding Graduate Student Poster Presentation Award
American Association of Veterinary Immunologists
Chicago, Illinois
1999-2000 Recipient, Presidential Fellowship
The Ohio State University
1999-2000 Recipient, Charles E. Thorne Memorial Assistantship
OARDC
1998 Recipient, Phi Kappa Phi Honor Society membership
The Ohio State University
1998 Recipient, Phi Zeta Student Research Award for poster presentation
College of Veterinary Medicine
The Ohio State University, at Advances in Veterinary Medicine Day
1994 Recipient, First Class Award for "Molecular epidemiology study of VP4 and VP7 genotypes of rotaviruses circulating in China" from Beijing Scientific and Technologic Invention
Municipal Committee of Science and Technology
Beijing, China

Professional Memberships

  • American Society for Virology, Full member
  • American Society for Microbiology
  • Society for Mucosal Immunology
  • American Association for the Advancement of Science
  • American Association of Veterinary Immunologists
  • Phi Kappa Phi National Honor Society
  • Phi Zeta, The National Honor Society of Veterinary Medicine

Selected Publications

  1. Liu F, Li G, Wen K, Wu S, Zhang Y, Bui T, Yang X, Kocher J, Sun J, Jortner B, Yuan L. 2013. Lactobacillus rhamnosus GG on rotavirus induced injury of ileal epithelium in gnotobiotic pigs. Journal of Pediatric Gastroenterology & Nutrition (doi: 10.1097/MPG.0b013e3182a356e1). in press.
  2. Liu F, Wen K, Li G, Yang X, Kocher J, Bui T, Jones D, Vonck M, Pelzer K, Yuan L. 2013. Dual functions of Lactobacillus acidophilus NCFMTMin protection against rotavirus diarrhea ingnotobiotic pigs vaccinated with a human rotavirus vaccine. Journal of Pediatric Gastroenterology & Nutrition (in press).
  3. Wentzel JF, Yuan L, Rao S, van Dijk A, O’Neill HG. 2013. Consensus sequence determination and elucidation of the evolutionary history of a rotavirus Wa variant reveal a close relationship to various Wa variants derived from the original Wa strain. Infection, Genetics and Evolution (doi: 10.1016/j.meegid.2013.09.007). in press.
  4. Wu S, Yuan L, Zhang Y, Liu F, Li G, Wen K, Kocher J, Yang X, Sun J. 2013. Probiotic LGG mono-association suppresses virus-induced autophagy in gnotobiotic pig intestine. Gut Pathog. 5:22-28.
  5. Bui T, Kocher J, Li Y, Wen K, Li G, Liu F, Yang X, LeRoith T, Tan M, Xia M, Zhong W, Jiang X, Yuan L. 2013. Median infectious dose of human norovirus GII.4 in gnotobiotic pigs is decreased by simvastatin treatment and increased by age. J. Gen Virol. 94:2005-2016.
  6. Wen K, Li G, Yang X, Bui T, Bai M, Liu F, Kocher J, Yuan L. 2012. CD4+CD25-FoxP3+ regulatory cells are the predominant responding regulatory T cells after human rotavirus infection or vaccination in gnotobiotic pigs. Immunology. 137:160-171.
  7. Wen K, Bui T, Li G, Liu F, Li Y, Kocher J, Yuan L. 2012. Characterization of immune modulating functions of γδ T cell subsets in a gnotobiotic pig model of human rotavirus infection. Comp Immunol Microbiol Infect Dis. 35:289-301.
  8. Wen K, Li G, Bui T, Liu F, Li Y, Kocher J, Lin L, Yang X, Yuan L. 2012. High dose and low dose Lactobacilli acidophilus exerted opposite immune modulating effects on T cell immune responses induced by an oral human rotavirus vaccine in gnotobiotic pigs. Vaccine 30:1198-1207.
  9. Wen K, Li G, Zhang W, Azevedo MSP, Saif LJ, Liu F, Bui T, Yousef A, Yuan L. 2011. Development of γδ T cell subset responses in gnotobiotic pigs infected with human rotaviruses and colonized with probiotic lactobacilli. Vet Immunol Immunopathol14:267–275.
  10. Liu F, Li G, Wen K, Bui T, Cao D, Zhang Y, Yuan L. 2010. Porcine small intestinal epithelial cell line (IPEC-J2) of rotavirus infection as a new model for study of innate immune responses to rotaviruses and probiotics. Viral Immunology. 2010. 23:135-149.

Please see Dr. Yuan's Biosketch (PDF) for more publications.