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DBSP Faculty

William R. Huckle

William R. Huckle, MS, PhD

Associate Professor
Cell Biology/Pharmacology
Department of Biomedical Sciences & Pathobiology
 
e-mail: wrhuckle@vt.edu
Capsule Biography (PDF)

Education

1988 Ph.D., Pharmacology
University of Iowa
Iowa City, Iowa
1981 M.S., Biochemistry
Virginia Tech
Blacksburg, Virginia
1978 B.A., Chemistry
Williams College
Williamstown, Massachusetts

Research Interests

  • Intracellular signaling mechanisms
  • Regulation of growth factor receptor expression
  • Maintenance and growth of blood vessels in cardiovascular disease and cancer
  • Transgenic models of human diseases

Professional Experience

1999-present   Associate Professor
VA-MD Regional College of Veterinary Medicine
Virginia Tech
1992-1999 Research Fellow
Merck & Company
West Point, Pennsylvania
1988-1992 Post-doctoral Fellow/Research Assistant Professor
University of North Carolina-Chapel Hill
1983-1984 Staff Biochemist
GIBCO-BRL/Life Technologies
Gaithersburg, Maryland

Professional Memberships

  • American Chemical Society
  • Endocrine Society
  • American Society for Cell Biology
  • North American Vascular Biology Organization
  • RNA Society

Selected Publications

  • Goldman, C.K., Kendall, R.L., Cabrera, G., Soroceanu, L., Heike, Y., Gillespie, G.Y., Siegal, G.P., Bett, A.J., Mao, X., Huckle, W.R., Thomas, K.A., and Curiel, D.T. (1998) Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis and mortality rate. Proc. Natl. Acad. Sci. USA 95:8795-8800.
  • Huckle, W.R., Drag, M.D., Acker, W.R., Powers, M., McFall, R.C., Holder, D.J., Walsh, T.F., Schwartz, R.S., Greenlee, W.J., and Johnson, R.G. (2001) Effects of L-749,329, an ETA/ETB endothelin receptor antagonist, in a porcine coronary artery injury model of vascular restenosis. Circulation 103:1899-1905.
  • Fraley, M.E., Rubino, R.S., Hoffman, W.F., Hambaugh, S.R., Arrington, K.L., Hungate, R.W., Bilodeau, M.T., Tebben, A.J., Rutledge, R.Z., Kendall, R.L., McFall, R.C., Huckle, W.R., Coll, K.E., and Thomas, K.A. (2002) Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics. Bioorg Med Chem Lett. 12:3537-3541.
  • Porter, R.M., Huckle, W.R., and Goldstein, A.S. (2003) Withdrawal of dexamethasone halts osteoblastic differentiation of bone marrow stromal cells, J. Cell. Biochem. 90:13-22.
  • Huckle, W.R, and Roche, R.I. (2004) Post-transcriptional control of expression of sFlt-1, an endogenous inhibitor of vascular endothelial growth factor, J. Cell. Biochem. 93:120-132.
  • Spillman, W.B. J.L. Robertson, W.R. Huckle, B.S. Govindan and K.E. Meissner (2004) Complexity, fractals, disease time, and cancer, Phys Rev E Stat Nonlin Soft Matter Phys. 70:061911.1-12.
  • Bilodeau, M.T., Balitza, A.E., Koester, T.J., Manley, P.J., Rodman, L.D., Buser-Doepner, C., Coll, K.E., Fernandes, C., Gibbs, J.B., Heimbrook, D.C., Huckle, W.R., Kohl, N., Lynch, J.J., Mao, X., McFall, R.C., McLoughlin, D., Miller-Stein, C.M., Rickert, K.W., Sepp-Lorenzino, L., Shipman, J.M., Subramanian, R., Thomas, K.A., Wong, B.K., Yu, S., Hartman, G.D. (2004) Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel. J Med Chem. 47:6363-6372.
  • Kreke, M.R., W.R. Huckle and A.S. Goldstein (2005) Intermittent fluid flow up-regulates osteoblastic maturation of bone marrow stromal cells in a temporally dependent manner Bone 36:1047-1055.
  • Hafez, S.A., W.R. Huckle and T. Caceci (2005) Anatomical, histological and genetic investigations of a sexually anomalous goat, Vet. Rec. (in press).
  • Troy, G.C., Huckle, W.R., Rossmeisl, J.H., Panciera, D., Lanz, O., Robertson, J.L., Ward, D.L. (2005) Endostatin and vascular endothelial growth factor concentrations in healthy dogs and dogs with selected neoplasias, J. Vet. Int. Med. (in press).
  • MacLean, H.N., J.A. Abbott, D.L. Ward, W.R. Huckle, D. Sisson and R.L. Pyle (2005) N-terminal atrial natriuretic peptide immunoreactivity in cats with hypertrophic cardiomyopathy, J. Vet. Int. Med. (in press).