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DBSP Faculty

William R. Huckle

William R. Huckle, MS, PhD

Associate Professor
Cell Biology/Pharmacology
Department of Biomedical Sciences & Pathobiology
 
e-mail: wrhuckle@vt.edu
Capsule Biography (PDF)


Education

1988 Ph.D., Pharmacology
University of Iowa
Iowa City, Iowa
1981 M.S., Biochemistry
Virginia Tech
Blacksburg, Virginia
1978 B.A., Chemistry
Williams College
Williamstown, Massachusetts

Research Interests

  • Intracellular signaling mechanisms
  • Regulation of growth factor receptor expression
  • Maintenance and growth of blood vessels in cardiovascular disease and cancer
  • Transgenic models of human diseases

Professional Experience

1999-present   Associate Professor
VA-MD Regional College of Veterinary Medicine
Virginia Tech
1992-1999 Research Fellow
Merck & Company
West Point, Pennsylvania
1988-1992 Post-doctoral Fellow/Research Assistant Professor
University of North Carolina-Chapel Hill
1983-1984 Staff Biochemist
GIBCO-BRL/Life Technologies
Gaithersburg, Maryland

Professional Memberships

  • American Chemical Society
  • Endocrine Society
  • American Society for Cell Biology
  • North American Vascular Biology Organization
  • RNA Society

Selected Publications

  1. Goldman, C.K., Kendall, R.L., Cabrera, G., Soroceanu, L., Heike, Y., Gillespie, G.Y., Siegal, G.P., Bett, A.J., Mao, X., Huckle, W.R., Thomas, K.A., and Curiel, D.T. (1998) Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis and mortality rate. Proc. Natl. Acad. Sci. USA 95:8795-8800.
  2. Huckle, W.R., Drag, M.D., Acker, W.R., Powers, M., McFall, R.C., Holder, D.J., Walsh, T.F., Schwartz, R.S., Greenlee, W.J., and Johnson, R.G. (2001) Effects of L-749,329, an ETA/ETB endothelin receptor antagonist, in a porcine coronary artery injury model of vascular restenosis. Circulation 103:1899-1905.
  3. Fraley, M.E., Rubino, R.S., Hoffman, W.F., Hambaugh, S.R., Arrington, K.L., Hungate, R.W., Bilodeau, M.T., Tebben, A.J., Rutledge, R.Z., Kendall, R.L., McFall, R.C., Huckle, W.R., Coll, K.E., and Thomas, K.A. (2002) Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics. Bioorg Med Chem Lett. 12:3537-3541.
  4. Porter, R.M., Huckle, W.R., and Goldstein, A.S. (2003) Withdrawal of dexamethasone halts osteoblastic differentiation of bone marrow stromal cells, J. Cell. Biochem. 90:13-22.
  5. Huckle, W.R, and Roche, R.I. (2004) Post-transcriptional control of expression of sFlt-1, an endogenous inhibitor of vascular endothelial growth factor, J. Cell. Biochem. 93:120-132.
  6. Spillman, W.B. J.L. Robertson, W.R. Huckle, B.S. Govindan and K.E. Meissner (2004) Complexity, fractals, disease time, and cancer, Phys Rev E Stat Nonlin Soft Matter Phys. 70:061911.1-12.
  7. Bilodeau, M.T., Balitza, A.E., Koester, T.J., Manley, P.J., Rodman, L.D., Buser-Doepner, C., Coll, K.E., Fernandes, C., Gibbs, J.B., Heimbrook, D.C., Huckle, W.R., Kohl, N., Lynch, J.J., Mao, X., McFall, R.C., McLoughlin, D., Miller-Stein, C.M., Rickert, K.W., Sepp-Lorenzino, L., Shipman, J.M., Subramanian, R., Thomas, K.A., Wong, B.K., Yu, S., Hartman, G.D. (2004) Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel. J Med Chem. 47:6363-6372.
  8. Kreke, M.R., W.R. Huckle and A.S. Goldstein (2005) Intermittent fluid flow up-regulates osteoblastic maturation of bone marrow stromal cells in a temporally dependent manner Bone 36:1047-1055.
  9. Hafez, S.A., W.R. Huckle and T. Caceci (2005) Anatomical, histological and genetic investigations of a sexually anomalous goat, Vet. Rec. (in press).
  10. Troy, G.C., Huckle, W.R., Rossmeisl, J.H., Panciera, D., Lanz, O., Robertson, J.L., Ward, D.L. (2005) Endostatin and vascular endothelial growth factor concentrations in healthy dogs and dogs with selected neoplasias, J. Vet. Int. Med. (in press).
  11. MacLean, H.N., J.A. Abbott, D.L. Ward, W.R. Huckle, D. Sisson and R.L. Pyle (2005) N-terminal atrial natriuretic peptide immunoreactivity in cats with hypertrophic cardiomyopathy, J. Vet. Int. Med. (in press).