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DBSP Faculty

Dr. Jia-Qiang He

Jia-Qiang He, PhD

Assistant Professor
Stem Cell Physiology
Department of Biomedical Sciences & Pathobiology
 
e-mail: jiahe@vt.edu

Education

1996 Ph.D., Physiology
Peking Union Medical College
China

Research Interests

  • Controlled cardiac lineage differentiation of embryonic stem cells, iPSCs & adult cardiac stem cells
  • iPSC reprograming and characterization
  • Electrophysiological and functional maturity of stem cell-derived cardiomyocytes
  • Stem cell tissue engineering
  • Applications and mechanisms of stem cell-based therapy for cardiovascular diseases

Professional Experience

2012-present Assistant Professor of Physiology
Department of Biomedical Sciences and Pathobiology
Virginia-Maryland Regional College of Veterinary Medicine
Virginia Tech
Blacksburg, VA
2009-2012 Assistant Professor
Departments of Medicine & Physiology & Biophysics
University of Louisville
Louisville, KY
2005-2009 Manager & Director
Cellular Dynamics International
Madison, WI
1999-2005 Assistant & Associate Scientist
University of Wisconsin
Madison, WI
1996-1999 Postdoc fellow
University of Wisconsin
Madison, WI

Professional Memberships

  • Member of the International Society for Stem Cell Research (ISSCR), 2006-present
  • Member of American Heart Association (AHA), 1999-present
  • Member of Biophysical Society of USA (BS), 1999-2005
  • Member of Cardiac Electrophysiology Society of USA (CES), 1999-2005

Selected Publications

  1. He J.-Q., Vu D.M., Hunt G., Chugh A., Bhatnagar A., Bolli R. Human Cardiac Stem Cells Isolated from Atrial Appendages Stably Express c-kit. PLoS One. 2011;6(11):e27719.
  2. Sale, H., Wang, J., O'Hara T.J., Tester, D.J., Phartiyal, P., He, J-Q., Rudy, Y., Ackerman, M.J., Robertson, G.A. Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with long-qt syndrome. Circ Res. 2008, 103:e81-e95.
  3. He, J.-Q., January, C.T., Thomson, J.A., and Kamp, T.J., Human Embryonic Stem Cell-Derived Cardiomyocytes: Drug Discovery/Safety Pharmacology. Expert Opinion on Drug Discovery, 2007, 2:739-753.
  4. Xu, C.H., He, J-Q., Kamp T.J., Police S., Hao, X.M., O's Sullivan, C., Carpenter, M.K., Lebkowski, J., and Gold J.D. Human embryonic stem cell-derived cardiomyocytes can be maintained in defined medium without serum. Stem Cells and Development, 2006, 15:931-941.
  5. He J.-Q., Balijepalli R.C., Haworth R.A., and Kamp T.J. Crosstalk of beta-adrenergic receptor subtypes through Gi blunts beta-adrenergic stimulation of L-type Ca2+ channels in canine heart failure. Circ Res. 2005 Sep 16;97(6):566-73.
  6. He, J-Q., Ma, Y., Causey J.A., Lee Y., Thomson J.A., and Kamp T.J. Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ Res. 2003, 93: 32-39.
  7. Kamp, T.J. and He, J-Q.. L-type Ca2+ channels gaining respect in heart failure. [Editorials] Circ Res, 2002, 91:451-453.
  8. He, J-Q., Conklin M.W., Foell J.D., Wolff M.R., Haworth R.A., Coronado R., and Kamp T.J. Reduction in density of transverse tubules and L-type Ca2+ channels in canine tachycardia-induced heart failure. Cardiovasc. Res. 2001, 49:298-307.
  9. He, J-Q., Pi, Y.Q., Walker, J.W. and Kamp, T.J. Endothelin-1 and photo-released diacylglycerol increase L-type Ca2+ current by activation of PKC in rat ventricular myocytes. J. Physiol. (London). 2000, 524:807-820.