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DBSP Faculty

Irving C. Allen

Irving C. Allen, MS, MBA, PhD

Assistant Professor
Inflammatory Disease
Department of Biomedical Sciences & Pathobiology
 
e-mail: icallen@vt.edu


Education

2012 MBA, Bioscience Management
North Carolina State University
2006 Ph.D., Genetics and Molecular Biology
The University of North Carolina at Chapel Hill
2000 M.S., Biology
The University of North Carolina at Greensboro
1997 B.S., Biology
East Carolina University

Research Interests

  • Cancer immunology
  • Animal models of innate immunity
  • Animal models of allergic disease
  • Host pathogen interactions

Professional Experience

2012-present Assistant Professor, Inflammatory Disease
Department of Biomedical Sciences and Pathobiology
VA-MD Regional College of Veterinary Medicine
Virginia Tech, Blacksburg, VA
2007-2011 Postdoctoral Fellow/Research Associate, Immunology
Lineberger Comprehensive Cancer Center
The University of North Carolina at Chapel Hill
Chapel Hill, NC
2001-2002 Research Associate
Center for Human Genetics
Duke University, Durham, NC
1997-2001 Laboratory Technologist I
Laboratory Corporation of America
Paternity Testing Division
Burlington, NC

Professional Memberships

  • American Association of Immunologists
  • Inflammation Research Association
  • American Association for the Advancement of Science
  • American Society for Microbiology
  • Society for Mucosal Immunology

Selected Publications

  1. Schneider,M., Zimmermann,A.G., Roberts,R., Zhang,L., Swanson,K.V., Wen,H., Davis,B.K., Allen,I.C., Holl,E.K., Ye,Z., Rahman,A.H., Conti,B.J., Eitas,T., Koller,B.H., and Ting,J.P.Y. (2012). NLRC3 Attenuates TLR Signaling via Modification of TRAF6 and NF-κB. Nature Immunology. September 13(9):823-31.
  2. Allen,I.C., Wilson,J.E., Schneider, M., Lich,J.D., Authur,J.C., Woodford,R.M., Uronis,J.M., Davis,B.K., Roberts,R.A., Rogers,A.B., Herfarth,H.H., Jobin,C., and Ting, J.P.Y. (2012). NLRP12 Functions as a Negative Regulator of Noncanonical NF-κB Signaling and Tumorigenesis during Colitis Associated Cancer. Immunity. May 25;36(5):742-54.
  3. Allen,I.C., Jania,C.M., Wilson, J.E., Tekeppe,E.M., Hua,X., Brickey,W.J., Kwan,M., Koller,B.H., Tilley,S.L., Ting,J.P.Y. (2012). Analysis of NLRP3 in the Development of Allergic Airway Disease in Mice. The Journal of Immunology. Mar 15;188(6):2884-93.
  4. Allen,I.C., Lich,J.D., Arthur,J.C., Jania, C.M., Roberts, R.A., Callaway, J.B., Tilley, S.L., Ting,J.P.Y. (2012). Characterization of NLRP12 during the Development of Allergic Airway Disease in Mice. PLoS One. Jan; 7(1): e30612.
  5. Cyphert,J.*, Allen,I.C.*, Cote,R.J., Latour,A.M., Snouwaert,J.N., Coffman,T.M., and Koller,B.H. (2011). Allergic Inflammation Induces a Persistent Mechanistic Switch in Thromboxane-Mediated Airway Constriction in the Mouse. The American Journal of Physiology - Lung Cellular and Molecular Physiology. Jan;302(1):L140-51. *Authors Contributed Equally.
  6. Allen,I.C., Moore, C.B., Schneider, M., Lei, Y., Davis, B.K., Scull, M.A., Gris, D., Roney, K.E., Zimmermann, A.G., Bowzard, J.B., Ranjan, P., Monroe, K.M., Vance, R.E., Pickles, R.J., Sambhara, S., Ting, J.P.Y. (2011). NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways. Immunity. Jun 24; 34(6): 854-865.
  7. Van Deventer, H. W., Burgents, J.E., Wu, Q.P., Brickey, W.J., McFadden, R.M., Allen, I.C., Serody, J.S., Ting, J.P.Y. (2010). The inflammasome component, NLRP3, impairs antitumor vaccine by enhancing accumulation of peritumoral myeloid derived suppressor cells. Cancer Research. Dec 15;70(24):10161-9.
  8. Allen, I.C., Tekippe, E.M., Woodford, R.M., Uronis, J.M., Holl, E.K., Rogers, A.B., Herfarth, H.H., Jobin, C., Ting, J.P.Y. (2010). The NLRP3 Inflammasome Functions as a Negative Regulator of Tumorigenesis during Colitis Associated Cancer. The Journal of Experimental Medicine. May 10;207(5):1045-56.
  9. Willingham, S.B.*, Allen, I.C.*, Bergstralh, D.T.*, Brickey, W.T., Taxman, D.J., Duncan, J.A. Ting, J.P.Y. (2009). Klebsiella pneumoniae induces IL-1β release and pyronecrosis through NLRP3. The Journal of Immunology. August;183(3): 2008-15.*Authors Contributed Equally.
  10. Allen, I.C., Scull, M.A., Moore, C.B., Holl, E.K., Taxman, D.J., Guthrie, E.H., Pickles, R.J., Ting, J.P.Y. (2009). The NLRP3 Inflammasome Is Essential for the Regulation of Innate Immune Responses to Influenza A Virus Infection. Immunity. Apr;30(4):556-65.

Dr. Allen's full CV (PDF)