Nammalwar Sriranganathan, BVSc, MVSc, PhD, Diplomate, ACVM
Department of Biomedical Sciences & Pathobiology
Capsule Biography (PDF)
||ECFVG, American Veterinary Medical Association
Licensed to practice veterinary medicine & surgery in the states of Washington & Oregon
||Ph.D., Molecular Biology
Oregon State University, Corvallis, Oregon
||M.V.Sc., Veterinary Microbiology
University of Agricultral Sciences, Bangalore, India
||B.V.Sc., Veterinary Medicine and Surgery
University of Agriculture Sciences, Bangalore, India
||Diplomate, American College of Veterinary Microbiologists
- Targeted drug delivery for intracellular pathogens - In the last few decades,
the emergence of drug resistant strains of Salmonella sp., Brucella sp., Mycobacterium
sp., etc. representing intracellular bacterial pathogens is manifesting into a global health
problem thereby raising new pharmaceutical challenges and necessitating the development
of an efficient and cost effective novel agent. My laboratory is aiming to achieve site specific
targeted drug delivery with increased bioavailability of antimicrobials/drugs using nanoparticles
as carriers. Our ultimate goal is to design and develop novel nanoparticle based drugs by
incorporating biological, engineering and chemical manufacturing principles for therapeutic
application of chronic infectious diseases i.e., tuberculosis, brucellosis and salmonellosis. In
addition, I also believe that development of nanoparticle based targeted drug delivery system
may provide new therapeutic opportunities for the use of vast array of unstable, toxic, and
insoluble antimicrobials (sitting on the shelves of drug companies), with minimum or no
deleterious side effects.
- Development of vaccines against bioterrorism agents -
My main interests are in understanding the host-parasite relationships, pathogenesis, virulence and their
applications in vaccine development. At present my research focuses mainly on Brucella. My research effort
is geared towards generation and testing of recombinant B. abortus RB51 vaccines against Anthrax, Tuberculosis,
Paratuberculosis, Rift Valley Fever and Neosporosis.Microarray development to study host/pathogen interactions.
- Bacteriophage based remediation of food borne Salmonella in poultry -
In the last six years, I initiated research to investigate the potential of phages as remedial agents in poultry. The
entire chromosomal sequence (86.165kb) of one broad host range Salmonella species-specific phage called Felix 01has been
determined. This was done to explore using such long-term surviving phages as therapeutic and or bioremedial agent against
drug resistant Salmonella. Exploring bioremediation processes to treat regulated medical waste.
- Enterotoxigenic E. coli - My early efforts were focused on the
isolation, purification and characterization of Heat-Stable Enterotoxin (STa). We were the first to show that
bovine enterotoxigenic E.coli (ETEC) produced an 18 amino acid peptide. We also demonstrated by amino acid
sequencing that bovine STa was similar, if not identical, to an 18-19 amino-acid peptide produced by human ETEC.
- Molecular Immunology - Characterization and quantitation of
cytokine mRNA expression in lymphocytes from mice.
- Vaccines & aging - effect of aging on immune response
Virginia Tech, Blacksburg, VA
Virginia Tech, Blacksburg, VA
Virginia Tech, Blacksburg, VA
Washington State University, Pullman, WA
||Intern, Veterinary Clinic
||Veterinary Surgeon, Civil Veterinary Hospital
Instructor, UAS, Bangalore, India
- American Society for Microbiology (1973-present)
- American College of Veterinary Microbiologists (1978-present)
- American Association of Veterinary Laboratory Diagnosticians (1979-present)
- Conference of Research Workers in Animal Diseases (1982-present)
View a comprehensive listing of Dr. Sriranganathan's publications (PDF) or browse
the selected publications below.
- Seleem MN, Boyle SM, Sriranganathan N. Brucella: A pathogen without classic virulence genes.
Vet Microbiol. 2007 Nov 29.
- High KP, Prasad R, Marion CR, Schurig GG, Boyle SM, Sriranganathan N. Outcome and immune
responses after Brucella abortus infection in young adult and aged mice.Biogerontology.
- Ramamoorthy S, Sanakkayala N, Vemulapalli R, Jain N, Lindsay DS, Schurig GS, Boyle SM,
Sriranganathan N. Prevention of vertical transmission of Neospora caninum in C57BL/6 mice
vaccinated with Brucella abortus strain RB51 expressing N. caninum protective antigens. Int J
Parasitol. 2007 Nov;37(13):1531-8
- Contreras-Rodriguez A, Seleem MN, Schurig GG, Sriranganathan N, Boyle SM, Lopez-Merino A.
Cloning, expression and characterization of immunogenic aminopeptidase N from Brucella melitensis.
FEMS Immunol Med Microbiol. 2006 Nov;48(2):252-6.
- Seleem MN, Ali M, Boyle SM, Mukhopadhyay B, Witonsky SG, Schurig GG, Sriranganathan N.
Establishment of a gene expression system in Ochrobactrum anthropi. Appl Environ Microbiol. 2006
- Honko AN, Sriranganathan N, Lees CJ, Mizel SB. Flagellin is an effective adjuvant for immunization
against lethal respiratory challenge with Yersinia pestis. Infect Immun. 2006 Feb;74(2):1113-20.
- Vemulapalli TH, Vemulapalli R, Schurig GG, Boyle SM, Sriranganathan N. Role in virulence of a
Brucella abortus protein exhibiting lectin-like activity. Infect Immun. 2006 Jan;74(1):183-91.
- Bandara AB, Sriranganathan N, Schurig GG, Boyle SM. Carboxyl-terminal protease regulates Brucella
suis morphology in culture and persistence in macrophages and mice. J Bacteriol.
- Whichard JM, Sriranganathan N, Pierson FW. Suppression of Salmonella growth by wild-type and
large-plaque variants of bacteriophage Felix O1 in liquid culture and on chicken frankfurters. J
Food Prot. 2003 Feb;66(2):220-5.
- Schurig GG, Sriranganathan N, Corbel MJ. Brucellosis vaccines: past, present and future.
Vet Microbiol. 2002 Dec 20;90(1-4):479-96. Review.
- Zhi-Jun Y, Sriranganathan N, Vaught T, Arastu SK, Ahmed SA. A dye-based lymphocyte proliferation
assay that permits multiple immunological analyses: mRNA, cytogenetic, apoptosis, and
immunophenotyping studies. J Immunol Methods. 1997 Dec 15;210(1):25-39.
- Schurig GG, Roop RM 2nd, Bagchi T, Boyle S, Buhrman D, Sriranganathan N. Biological properties
of RB51; a stable rough strain of Brucella abortus. Vet Microbiol. 1991 Jul;28(2):171-88.
- Sriranganathan N, Boyle SM, Schurig G, Misra H. Superoxide dismutases of virulent and avirulent
strains of Brucella abortus. Vet Microbiol. 1991 Feb 15;26(4):359-66.
- Sriranganathan N, Burger D. Heat-stable (STa) enterotoxin of enterotoxigenic Escherichia coli:
binding of the enterotoxin to coagulated milk and casein.Vet Microbiol. 1987 Feb;13(2):167-78.
- Sriranganathan N, Seidler RJ, Sandine WE, Elliker PR. Cytological and deoxyribonucleic
acid-deoxyribonucleic acid hybridization studies on lactobacillus isolates from San Francisco
sourdough. Appl Microbiol. 1973 Mar;25(3):461-70.